Análise crítica da dosagem de creatinofosfoquinase no Pronto-Socorro Central do Hospital da Irmandade da Santa Casa de Misericórdia de São Paulo / Critical analysis of the creatine phosphoquinase dosage in the Emergency Department of Sao Paulo’s Santa Casa de Misericordia Hospital

Alves, Marina Miury Sato Rodrigues; Nakagome, Beatriz Harumi Yuda; Traldi, Maria Clara de Camargo; Guachala, Mila Carvalho; Kawakami, Nathalia T.; Yamaoka, Pedro Henrique Tsuyoshi; Pereira, Afonso Celso

doi:10.26432/1809-3019.2019.64.1.001

Cited by 3 publications

References 11 publications

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Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic®): a toxicological study in Wistar rats

et al. 2023

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Bixa orellana L. is a plant popularly known as "ucurum", "annatto", and "achiote". It is native to South America, and its seeds are an abundant source of geranylgeraniol and tocotrienols. Nanoencapsulation is a valuable technique that can decrease the drug needed to achieve an effect, decreasing potential toxicity and side effects. This study aimed to evaluate the acute toxicity of an intramuscular application of a nanodispersion containing a standardized extract (Chronic®) from the seeds of Bixa orellana (NBO) in Wistar rats. The chemical evaluation showed δ-tocotrienol at 0.725 ± 0.062 mg/ml (72.6 ± 0.9%). The stability study showed the nanoparticles had an average size from 53.15 ± 0.64 nm to 59.9 ± 3.63 nm, with a polydispersity index ranging from 0.574 ± 0.032 to 0.574 ± 0.32, Zeta potential from 18.26 ± 0.59 mV to 19.66 ± 1.45 mV. After testing the intramuscular application of NBO with doses from 1 to 5 mg/kg in animals, it was observed that the acute treatment did not elicit any toxic effects within this range. The dose of 10 mg/kg, although not affecting hematological and biochemical parameters (CPK, LDH, myoglobin, AST, ALT), could induce some muscle tissue changes, including leukocyte in ltration, morphological chances, and potentially necrosis. In conclusion, the results showed that the treatments devoided toxicity between 1 mg/kg and 5 mg/kg.

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Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic®): a toxicological study in Wistar rats

et al. 2023

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Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method

Gonçalves,

Araújo,

de Oliveira Carvalho

et al. 2023

Rev. Bras. Farmacogn.

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Intramuscular compatibility of an injectable nanodispersion anti-inflammatory (Chronic®) from a standardized Bixa orellana oil: a toxicological study in Wistar rats

Carvalho

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et al. 2022

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Bixa orellana L. is a plant popularly known as “ucurum”, “annatto”, and “achiote”. It is native to South America, and its seeds are an abundant source of geranylgeraniol and tocotrienols. Nanoencapsulation is a valuable technique that can decrease the drug needed to achieve an effect, decreasing potential toxicity and side effects. This study aimed to evaluate the acute toxicity of an intramuscular application of a nanodispersion containing a standardized extract (Chronic®) from the seeds of Bixa orellana (NBO) in Wistar rats. The chemical evaluation showed δ-tocotrienol at 0.725 ± 0.062 mg/ml (72.6 ± 0.9%). The stability study showed the nanoparticles had an average size from 53.15 ± 0.64 nm to 59.9 ± 3.63 nm, with a polydispersity index ranging from 0.574 ± 0.032 to 0.574 ± 0.32, Zeta potential from 18.26 ± 0.59 mV to 19.66 ± 1.45 mV. After testing the intramuscular application of NBO with doses from 1 to 5 mg/kg in animals, it was observed that the acute treatment did not elicit any toxic effects within this range. The dose of 10 mg/kg, although not affecting hematological and biochemical parameters (CPK, LDH, myoglobin, AST, ALT), could induce some muscle tissue changes, including leukocyte infiltration, morphological chances, and potentially necrosis. In conclusion, the results showed that the treatments devoided toxicity between 1 mg/kg and 5 mg/kg.

show abstract

Análise crítica da dosagem de creatinofosfoquinase no Pronto-Socorro Central do Hospital da Irmandade da Santa Casa de Misericórdia de São Paulo / Critical analysis of the creatine phosphoquinase dosage in the Emergency Department of Sao Paulo’s Santa Casa de Misericordia Hospital

Cited by 3 publications

References 11 publications

Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic®): a toxicological study in Wistar rats

Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic®): a toxicological study in Wistar rats

Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method

Intramuscular compatibility of an injectable nanodispersion anti-inflammatory (Chronic®) from a standardized Bixa orellana oil: a toxicological study in Wistar rats

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