Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

Gaffney, Vanessa de Jesus; Cardoso, Vítor Vale; Rodrigues, Alexandre; Ferreira, Elisabete; Benoliel, Maria João; Almeida, Cristina

doi:10.1590/s0100-40422014000100023

Cited by 40 publications

(37 citation statements)

References 30 publications

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“…Studies conducted by Kasprzyk-Hordern et al [34] in the Taff River, United Kingdom, and in the Warta River, Poland, showed that sulfamethoxazole was determined with a concentration between 26 and 60 ng•L −1 . The maximum value in surface waters for sulfamethoxazole in Portugal was 8.0 ng•L −1 in the Tejo and Zêzere rivers [14]. High concentrations of sulfamethoxazole were detected in the Nairobi River, Nigeria, and were related to the large amounts of consumption of this antibiotic in the country.…”

Section: River Water Analysismentioning

confidence: 91%

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Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

Monteiro¹,

Spisso²,

Santos³

et al. 2016

JEP

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The occurrence of antimicrobials in the aquatic environment and drinking water has raised the question of their impact on the environment and public health. Animal production is one of the most expressive activities of Brazilian agribusiness. In order to ensure the productivity and competitiveness of the sector, the use of drugs for therapeutic and prophylactic purposes is a common practice. Due to the continuous release of antimicrobials into the environment, the aim of this study was to compare the frequency of detection of tetracyclines and sulfonamides in surface water collected from rural areas in Lidice District of Rio Claro, in the State of Rio de Janeiro, Brazil. An investigative study was conducted with 24 river water samples analyzed by high-performance liquid chromatography coupled to tandem mass spectrometry and the aim of this study was to determine residues of sulfonamides and tetracyclines based on the USEPA me- M. A. Monteiro et al.231

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Section: River Water Analysismentioning

confidence: 91%

“…Different adverse effects of pharmaceutical compounds have been described including aquatic toxicity, development of resistance in pathogenic bacteria, genotoxicity and endocrine disorders [12]- [14].…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

Monteiro¹,

Spisso²,

Santos³

et al. 2016

JEP

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“…Diversos grupos de substâncias têm sido considerados contaminantes emergentes, incluindo cianotoxinas, micotoxinas, aditivos de gasolina e industriais, retardantes de chama bromados, hormônios esteróides, surfactantes, produtos farmacêuticos e de cuidado pessoal, compostos polifluoretados, nanomateriais e subprodutos de desinfecção, bem como os metabólitos resultantes dos mesmos (FARRÉ et al, 2008;GAFFNEY et al, 2014).…”

Section: Introductionunclassified

“…Podemos considerar a presença de compostos introduzidos recentemente no meio ambiente, os quais ainda não se conhecem seus efeitos ao ambiente e à saúde humana, e os compostos não tão recentes, que têm despertado atenção em todo o mundo devido a suspeita de seus efeitos prejudiciais causados pela exposição crônica (GAFFNEY et al, 2014).…”

Section: Introductionunclassified

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Detecção De Progesterona Em Tecidos Vegetais De Lactuca Sp. Por Espectroscopia De Uv

Fabbris¹,

Nicolini²

2017

MUNDI SB

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Resumo: A sociedade pós-moderna usa diversas substâncias para melhorar a sua qualidade de vida. Inúmeras dessas substâncias são fármacos e muitos desses já são considerados contaminantes emergentes e presentes em diversos locais devido à ação antrópica. Há uma preocupação da comunidade científica mundial no sentido de monitorar os contaminantes emergentes e estabelecer protocolos de quantificação que possam estabelecer limites de tolerância dessas substâncias e assim proteger as comunidades humanas de possíveis problemas de saúde advindos dessa contaminação. Há indícios de inúmeros contaminantes emergentes (antimicrobianos, fungicidas, hormônios, anti-inflamatórios) em águas de superfície e em alimentos. O objetivo do presente trabalho foi avaliar a presença de progesterona em tecidos vegetais da alface (Lactuca sp.) através da espectroscopia ultravioleta (UV). As plantas foram cultivadas in vitro e testadas frente a diferentes concentrações de progesterona (5,10,100 e 1000 ppm). A parte da planta coletada para análise foi as folhas, utilizou-se como solvente etanol 92,8 o GL. Foi detectada a presença de progesterona após o intervalo de um dia da contaminação do substrato até o oitavo dia, sendo que as concentrações encontradas foram entre 0,14 e 1,11 ppm no extrato etanólico das folhas. Esse estudo indica a potencial contaminação de plantas, quando estas são irrigadas com água proveniente de mananciais contaminados com progesterona e seus metabólitos o que significa o consumo indireto desses contaminantes pela população, por meio da ingestão de plantas contaminadas. Palavras-chave: Contaminantes emergentes. Hormônios. Saúde humana.Abstract: Postmodern society uses various substances to improve their quality of life. Many of these substances are drugs and many of these are already considered emerging contaminants and present in various locations due to human action. There is a concern of the international scientific community to monitor emerging contaminants and establish quantification protocols that may establish tolerance limits of these substances and thus protect human communities from possible health problems resulting from this contamination. There is evidence of numerous emerging contaminants (antimicrobials, fungicides, hormones, anti-inflammatory drugs) in surface waters and foods. The aim of this study was to evaluate the presence of progesterone in tissues of lettuce (Lactuca sp.) by ultraviolet spectroscopy (UV). The plants were grown in vitro and tested against different concentrations of progesterone (5,10,100 and 1000 ppm). The part of the plant collected for analysis was the leaves. It was used as solvent the ethanol 92.8 o GL. It was detected the presence of progesterone after the interval of a day of substrate contamination until the eighth day, and the concentrations found were between 0,14 and 1,11 ppm in the ethanol extract of the leaves. This study indicates the potential contamination of plants, when they are irrigated with water from water sources contaminated with progesterone and its m...

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Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water

Gaffney¹,

Mota-Filipe

Pinto

et al. 2016

Enviro Toxic and Chemistry

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The water constituents that are currently subject to legal control are only a small fraction of the vast number of chemical substances and microorganisms that may occur in both the environment and water resources. The main objective of the present study was to study the health impact resulting from exposure to a mixture of pharmaceuticals that have been detected in tap water at low doses. Analyses of atenolol, caffeine, erythromycin, carbamazepine, and their metabolites in blood, urine, feces, fat tissue, liver, and kidney after exposure to a mixture of these pharmaceuticals in treated drinking water were performed. The effects of this exposure were assessed in rats by measuring biochemical markers of organ injury or dysfunction. Simultaneously, the selected pharmaceuticals were also quantified in both physiological fluids and organ homogenates by liquid chromatography-tandem mass spectrometry (performed in multiple reaction monitoring mode and full scan mode). Following exposure of rats to a concentration of a pharmaceutical which was 10 times higher than the concentration known to be present in tap water, trace levels of some pharmaceuticals and their metabolites were detected in biological samples. This exposure did, however, not lead to significant organ injury or dysfunction. Thus, the authors report an experimental model that can be used to characterize the safety profile of pharmaceuticals in treated drinking water using a multiorgan toxicity approach. Environ Toxicol Chem 2016;35:2674-2682. © 2016 SETAC.

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Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

Cited by 40 publications

References 30 publications

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

Detecção De Progesterona Em Tecidos Vegetais De Lactuca Sp. Por Espectroscopia De Uv

Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water

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