Análise espaço-temporal da doença de Chagas e seus fatores de risco ambientais e demográficos no município de Barcarena, Pará, Brasil

Júnior, Alcinês da Silva Sousa; Palácios, Vera Regina da Cunha Menezes; Miranda, Cláudia do Socorro Carvalho; Costa, Rodrigo Junior Farias da; Catete, Clístenes Pamplona; Chagasteles, Eugenia Janis; Pereira, Alba Lucia Ribeiro Raithy; Gonçalves, Nelson Veiga

doi:10.1590/1980-5497201700040015

Cited by 17 publications

(17 citation statements)

References 36 publications

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“…Therefore, as these are low-educated and low-income populations, these factors stand in the way of optimized clinical treatment and control of disease progression, contributing to the fact that CD remains a risk factor for negative outcomes in HF patients. 18,19 Martinelli et al 20 conducted a study of 116 patients with CD who implanted ICD for secondary prevention, with a lower mortality rate than our study (26.7% deaths over a mean follow-up of 45 months, 7.1% annual mortality rate). The higher mortality seen in our population can be explained by the severity profile of our patients, with higher prevalence of NYHA class III or IV and lower LVEF.…”

Section: Resultsmentioning

confidence: 46%

“…Another possible cause for our results is the social profile of these patients with CD, since a considerable part of these patients have low family income and low education. Therefore, as these are low‐educated and low‐income populations, these factors stand in the way of optimized clinical treatment and control of disease progression, contributing to the fact that CD remains a risk factor for negative outcomes in HF patients …”

Section: Discussionmentioning

confidence: 99%

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Chagas disease is associated with a worse prognosis at 1‐year follow‐up after implantable cardioverter‐defibrillator for secondary prevention in heart failure patients

Melo

Azevedo

Lira

et al. 2019

Cardiovasc electrophysiol

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Introduction There are conflicting data regarding the efficacy of implantable cardioverter‐defibrillator (ICD) in Chagas disease (CD) patients. This study aims to evaluate the short‐term outcome after ICD for secondary prevention, in a population where CD is a prevalent cause of heart failure (HF). Methods and Results Consecutive patients with HF and reduced left ventricular ejection fraction (LVEF), who underwent ICD implantation for secondary prevention of SCD. Clinical and demographic data were collected to investigate mortality predictors at 1 year. During the study period, 117 patients underwent ICD implantation, of which 108 were included. The most frequent causes of HF was CD: 52 (48.1%) and ischemic cardiomyopathy: 20 (18.5%). Chagas and non‐Chagas patients were well balanced—male: 32 (61.5%) vs 38 (67.9%), P = .548; age: 59.2 (±10.9) vs 56.8 (±13.4), P = .681; and LVEF: 34.1 (±0.2) vs 31.3 (±8.7), P = .064, respectively. At the mean follow‐up of 15.7 months, overall mortality occurred in 14 (12.9%) patients, with a higher incidence in patients with CD cardiomyopathy, 11 (21.2%) vs 3 (5.4%), P = .021 (log‐rank). In the multivariate analysis, CD remained as an independent predictor for death (hazard ratio: 4.62, confidence interval [95% CI]: 1.27‐16.81, P = .021). Conclusion CD was associated with a poor short‐term outcome in patients with HF submitted to ICD implantation for secondary prevention when compared with other HF etiologies. In this specific HF population, ICD indication should be individualized, considering the worst prognosis of these patients.

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Section: Resultsmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Chagas disease is associated with a worse prognosis at 1‐year follow‐up after implantable cardioverter‐defibrillator for secondary prevention in heart failure patients

Melo

Azevedo

Lira

et al. 2019

Cardiovasc electrophysiol

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“…The age group that is most frequently affected in this study corroborates with that in other studies. This finding indicates that the risk of CD infection increases during the most productive age of the individual and in those living in rural areas; during this period, the individual's most common activities were plant extraction and farming 15,16 .…”

Section: Discussionmentioning

confidence: 91%

Chagas Disease in the Western Brazilian Amazon: Epidemiological Overview from 2007 to 2018

Madeira

Jesus

Moraes

et al. 2021

jhgd

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Introduction: Chagas disease (CD) is a disease caused by the protozoan flagellates of the Kinetoplastid order Trypanosoma cruzi. Approximately 8,000,000 people are infected worldwide, mainly in Latin America, causing disabilities and more than 10,000 deaths per year. Objective: This study aimed to describe the epidemiological panorama of CD in the Western Brazilian Amazon from 2007 to 2018. Methods: In this ecological study, secondary data regarding the confirmed cases of T. cruzi infection in the states of Acre, Amazonas, Rondônia, and Roraima were collected from the Single Health System Notification Information System of the Department of Informatics of the Single Health System and were analyzed. The data were used to characterize the epidemiological profile of T. cruzi infection and to determine the frequency of infection in Western Amazonia. Results: A total of 184 cases of CD were reported in Western Amazonia, and the highest number of cases was reported in the states of Amazonas and Acre. Conclusion: The epidemiological panorama of the Western Brazilian Amazon from 2007 to 2018 includes a greater number of cases of T. cruzi infection in men aged 20–39 years and those living in rural areas. Oral transmission was prevalent in the region during the study, and the highest number of cases was reported in the months of April and December. Epidemiological data are an important resource for understanding the dynamics of CD and the main aspects related to the health-disease process.

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“…Deforestation carried out in the broad and unrestricted way in tropical forests is far from being just a moral problem―it is about to become a public health problem [ 35 ]. Studies have already shown that deforestation can lead to increased transmission of malaria [ 36 ], hantavirus [ 22 ], visceral leishmaniasis [ 37 ], and Chagas disease [ 38 ], to name just a few known examples. In the present study, we obtained evidence that accumulated deforestation between 30 and 70% and the fragmentation of the remaining forest equal to or above 80 m/ha, on the municipality scale, are associated with the occurrence of YF in Brazil, 2014–2019.…”

Section: Discussionmentioning

confidence: 99%

Reemergence of Yellow Fever in Brazil: The Role of Distinct Landscape Fragmentation Thresholds

Ilacqua

Medeiros‐Sousa

Ramos

et al. 2021

Journal of Environmental and Public Health

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Yellow Fever Virus (YFV) reemergence in Brazil was followed by human suffering and the loss of biodiversity of neotropical simians on the Atlantic coast. The underlying mechanisms were investigated with special focus on distinct landscape fragmentation thresholds in the affected municipalities. An ecological study in epidemiology is employed to assess the statistical relationship between events of YFV and forest fragmentation in municipal landscapes. Negative binomial regression model showed that highly fragmented forest cover was associated with an 85% increase of events of YFV in humans and simians (RR = 1.85, CI 95% = 1.24–2.75, p = 0.003 ) adjusted by vaccine coverage, population size, and municipality area. Intermediate levels of forest cover combined with higher levels of forest edge densities contribute to the YFV dispersion and the exponential growth of YF cases. Strategies for forest conservation are necessary for the control and prevention of YF and other zoonotic diseases that can spillover from the fragmented forest remains to populated cities of the Brazilian Atlantic coast.

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Análise espaço-temporal da doença de Chagas e seus fatores de risco ambientais e demográficos no município de Barcarena, Pará, Brasil

Abstract: Different relationships among the variables studied and the occurrence of the disease in the municipality were observed. The technologies used were satisfactory to construct the disease epidemiological scenarios.

Cited by 17 publications

References 36 publications

Chagas disease is associated with a worse prognosis at 1‐year follow‐up after implantable cardioverter‐defibrillator for secondary prevention in heart failure patients

Chagas disease is associated with a worse prognosis at 1‐year follow‐up after implantable cardioverter‐defibrillator for secondary prevention in heart failure patients

Chagas Disease in the Western Brazilian Amazon: Epidemiological Overview from 2007 to 2018

Reemergence of Yellow Fever in Brazil: The Role of Distinct Landscape Fragmentation Thresholds

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