Análisis económico de las vacunas del primer año de vida con componente pertussis en el contexto de la ini-ciativa mundial de erradicación de la poliomielitis en Argentina

Gentile, Ángela; Giglio, Norberto; Castellano, Vanesa; López, Juan Guillermo; Dibarboure, Hugo

doi:10.4067/s0716-10182021000200224

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Previous studies found that a switch from the pentavalent vaccine plus IPV/oral polio vaccine to the hexavalent vaccine from the Chilean and Argentinean societal perspectives would result in incremental costs of US$6.45 M and US$19.7 M, respectively [ 14 , 40 ], which are much higher than in our current study. The study undertaken in Chile (and the previous Argentinean study) did not have programmatic costs from Portnoy et al 2020 [ 37 ] available at the time of their analyses, but which we included.…”

Section: Discussioncontrasting

confidence: 63%

Cost minimization analysis of a hexavalent vaccine in Argentina

Olivera,

Pérez,

Lazarov

et al. 2023

BMC Health Serv Res

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Background Argentina currently uses a pentavalent vaccine containing diphtheria, tetanus, pertussis (whole cell), Haemophilus influenza type b and hepatitis B antigens, administered concomitantly with the inactivated polio vaccine (IPV) (DTwP-Hib-HB plus IPV) in its childhood vaccination schedule. However, hexavalent vaccines containing acellular pertussis antigens (DTaP-Hib-HB-IPV) and providing protection against the same diseases are also licensed, but are only available with a private prescription or for high-risk pre-term infants in the public health program. We analyzed the cost of switching from the current schedule to the alternative schedule with the hexavalent vaccine in Argentina, assuming similar levels of effectiveness. Methods The study population was infants ≤ 1 year of age born in Argentina from 2015 to 2019. The analysis considered adverse events, programmatic, logistic, and vaccine costs of both schemes from the societal perspective. The societal costs were disaggregated to summarize costs incurred in the public sector and with vaccination pre-term infants in the public sector. Costs were expressed in 2021 US Dollars (US$). Results Although the cost of vaccines with the alternative scheme would be US$39.8 million (M) more than with the current scheme, these additional costs are in large part offset by fewer adverse event-associated costs and lower programmatic costs such that the overall cost of the alternative scheme would only be an additional US$3.6 M from the societal perspective. The additional cost associated with switching to the alternative scheme in the public sector and with the vaccination of pre-term infants in the public sector would be US$2.1 M and US$84,023, respectively. Conclusions The switch to an alternative scheme with the hexavalent vaccine in Argentina would result in marginally higher vaccine costs, which are mostly offset by the lower costs associated with improved logistics, fewer separate vaccines, and a reduction in adverse events.

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Section: Discussioncontrasting

confidence: 63%