The process of learning activities can not be separated from learning media. Learning mediaused has not been able to remediate misconceptions. The mediacan be used in remediating misconceptions, namely PJBL-based interactive e-module with a scientific approach. This research is R&D research with a development model ADDIE (Analysis, Design, Development, Implementation, Evaluation). The instrument used, Four Tier diagnostic test. Test to find out misconceptions, e-module validation questionnaire given to media experts, material experts and language experts to test and determine the feasibility of the e-module and response educators regarding e-modules and student questionnaires for testing limited trial and extensive trial. The data analysis technique uses descriptive quantitative. The research results show the value of expert suitability media is very decent, namely 89%, the value of material experts is very good decent, namely 90%, very decent linguist score, namely 94%, test score try educators very worthy 89%, limited trials very decent 84%, and widely tested value very feasible 80%, shows that the e-module is suitable for use. Results from n-gain effectiveness test 71.4%, e-module PJBL-based interactive with a scientific approach is quite effective in remediating students’ misconceptions about structural material and the function of plant tissue.