Introduction: Pneumonia is inflammation in the lung parenchyma. Inflammation occurs due to infection by various organisms like bacteria, viruses, and others. This infection eventually causes the emergence of several signs and symptoms. Ceftriaxone and cefotaxime are antibiotics that are commonly and effectively used in the treatment of pneumonia. Methods: The purpose of this study is to determine the total cost of pneumonia treatment provided during hospitalization at RSUD Bekasi City. This research
uses the method descriptive research with data retrieval retrospectively. The sample in this research totaled 68 patients, 34 patients used ceftriaxone antibiotics and 34 patients used cefotaxime antibiotics. Results: Cefotaxime antibiotic therapy is a more cost-effective therapy compared to Ceftriaxone. This study found the effectiveness of Ceftriaxone 88% and Cefotaxime 70% but did not reach 100% effectiveness due to the large number of patients whose length of stay (LOS) and respiration rate (RR) did not reach the target. The result showed that the average cost of treating patients with Ceftriaxone was Idr 2,171,651 and the average cost of treating patients with Cefotaxime was Idr 2,467,422. Conclusion: Ceftriaxone antibiotic therapy is a more cost-effective therapy compared to Cefotaxime which can be, seen from the ACER Ceftriaxone value of IRp. 24,677 and ICER value of Rp. -16,431.651 and the average cost of treating patients using Cefotaxime was Idr 2,467,422.