This study aims to build a SEARC mathematical model of drug addiction in South Sulawesi. The purpose of this study was to analyze and predict the number of drug addiction cases in South Sulawesi. The data used in this study is secondary data from the Provincial National Narcotics Agency (BNNP) of South Sulawesi and the Rehabilitation Center of the National Narcotics Agency (BNN) Baddoka Makassar. The steps in this study are to make assumptions and determine the SEARC model for drug addiction, determine the equilibrium point of the model obtained, analyze the stability of the equilibrium point, perform simulations with the Maple program, and conclude. The results of this study obtained the SEARC mathematical model of drug addiction in the form of a five dimensional system of differential equations, and also obtained an addiction-free equilibrium point and a stable endemic equilibrium point, as well as the basic reproduction number R0= 0.05 which shows that the rate of drug addiction cases in South Sulawesi can be controlled but preventive measures still need to be taken. Based on the simulation, it is found that the rehabilitation program can reduce the number of drug addicts so that by improving rehabilitation facilities and services, it can reduce the number of drug addicts effectively.