Análisis y protocolización de la utilización de rasburicasa en pacientes con neoplasias hematológicas

Abstract

A high variability is observed in the use of rasburicase in our patients. The hematology and pharmacy services have been working jointly to prepare a consensus-based protocol according to which, depending on the patient s risk of developing TLS (tumoral lysis syndrome), standard prophylaxis is administered to low-risk patients (intravenous hydration, alopurinol and urine alcalinization) and rasburicase is administered initially for 1-3 days to patients with high risk of developing TLS.

Rasburicase in the management of tumor lysis: an evidence-based review of its place in therapy

“… Notes: * Results of pooled response in PUA were only reported by Lascombes, 46 Jeha, 31 Bosly, 47 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 Knoebel, 54 Vines, 55 Yim, 56 Trifilio, 57 , 58 Steel, 59 and Chow 60 instead of all 21 studies, which is reflected by n=913 instead of n=1,261; ** results of serial PUA levels were only reported by Pui, 24 Rényi, 23 and Sanchez-Tatay, 25 instead of all seven studies, which is reflected by n=306 instead of n=1,274. Additionally, only Rényi 23 and Sanchez-Tatay 25 reported results for days 3 and 4; only Sanchez-Tatay reported results for days 5 and 7.…”

“… * Results of pooled response in PUA were only reported by Lascombes, 46 Jeha, 31 Bosly, 47 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 Knoebel, 54 Vines, 55 Yim, 56 Trifilio, 57 , 58 Steel, 59 and Chow 60 instead of all 21 studies, which is reflected by n=913 instead of n=1,261; …”

“… Notes: * Pooled results for need for RRT were only reported by Patte, 34 Pui, 24 Rényi, 23 Sanchez-Tatay, 25 and Wössmann 35 , which is reflected by n=992 instead of n=1,274; † pooled results for TLS were only reported by Ho, 50 Hutcherson, 51 and Llinares 52 . Pooled results for need for RRT were only reported by Lascombes, 46 Jeha, 31 Bosly, 47 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 and Steel 59 .…”

“… Notes: * Pooled results for need for RRT were only reported by Patte, 34 Pui, 24 Rényi, 23 Sanchez-Tatay, 25 and Wössmann 35 , which is reflected by n=992 instead of n=1,274; † pooled results for TLS were only reported by Ho, 50 Hutcherson, 51 and Llinares 52 . Pooled results for need for RRT were only reported by Lascombes, 46 Jeha, 31 Bosly, 47 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 and Steel 59 . This is reflected by n=42 for TLS and n=702 for AKI instead of n=1,261; †† pooled results for mortality due to TLS were only reported by Patte, 34 Rényi, 23 and Sanchez-Tatay 25 , which is reflected by n=396 instead of n=1,274, and pooled results for all-cause mortality were only reported by Rényi, 23 Sanchez-Tatay, 25 and Wössmann 35 , which is reflected by n=406 instead of n=1,274; ‡ pooled results for mortality were only reported by Jeha, 31 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 and Steel 59 .…”

“… † pooled results for TLS were only reported by Ho, 50 Hutcherson, 51 and Llinares 52 . Pooled results for need for RRT were only reported by Lascombes, 46 Jeha, 31 Bosly, 47 Coiffier, 41 Pohlreich, 48 Wang, 49 Ho, 50 Hutcherson, 51 Llinares, 52 Campara, 53 and Steel 59 . This is reflected by n=42 for TLS and n=702 for AKI instead of n=1,261; …”