Analiza czynników rokowniczych u chorych z miejscowo zaawansowanym rakiem krtani

Abstract

The 3-year overall survival (OS) was 58%. Margin status and numer of risk factors had impast on OS. The 3-year locoregional control (LRC) was 80%. Number of risk factors, level of hemoglobin, overall tratment time and dose were significantly associated with LRC. Incidence of distant metastases was asssociated with G3 suamous cell carcinoma and index of nalignancy H. Glanz.

Postoperative irradiation in patients with pT3-4N0 laryngeal cancer: results and prognostic factors

“…Our results did not show prognostic significance of the trachea involvement, which is in line with the literature [ 17 , 18 , 23 , 26 ].…”

“…In our material macroscopically positive surgical margins were noticed only in four patients, in most cases (60 %) they were positive microscopically. According to the literature this percentage varies from 20 to 70 % [ 12 , 17 , 18 , 25 , 26 ]. In our study group, as in other papers, low and intermediate grade of tumor differentiation were most common.…”

“…DFS5 for patients with negative surgical margins (R0) was 82 %, compared to 72 % for a microscopically positive margins (R1) ( p = 0.013). In a series of 111 patients irradiated postoperatively at the Radiotherapy Department of Pomeranian Medical University, 3-year survival for R0 and R1 was 61 and 41 %, respectively ( p = 0.005) [ 26 ]. The potential prognostic role of radical surgery is emphasized by Hinerman et al, who reported five-year locoregional control (LRC5) of 56 and 89 % ( p = 0.075) for negative and positive surgical margins, respectively [ 17 ].…”

“…The corresponding median cancer-specific survivals were 56 vs 21 months, but the difference in survival was not statistically significant ( p = 0.460) [ 30 ]. Kubrak and colleagues from the Department of Radiotherapy at Pomeranian Medical University have found that the risk of distant metastases increased three times (21 vs 7 %) with an increase in the malignancy index [ 26 ].…”