Analog simulation of aortic and of mitral regurgitation

Dolenšek, Janez; Podnar, Tomaž; Runovc, Franc; Kordaš, M.

doi:10.1016/j.compbiomed.2009.03.009

Cited by 7 publications

(12 citation statements)

References 11 publications

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“…Recent approaches available online as free software also include negative feedback, e.g., showing the time course of renin concentration after a sudden decrease of NaCl ingestion (1,30). However, using EECs, quite complex clinically important conditions can be qualitatively, sometimes even quantitative well simulated (38,39,50,17). Variables can be displayed not only over a relatively large time span but also within one heart cycle.…”

Section: How We Teachmentioning

confidence: 99%

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Teaching cardiovascular physiology with equivalent electronic circuits in a practically oriented teaching module

Ribarič

Kordaš

2011

Advances in Physiology Education

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Here, we report on a new tool for teaching cardiovascular physiology and pathophysiology that promotes qualitative as well as quantitative thinking about time-dependent physiological phenomena. Quantification of steady and presteady-state (transient) cardiovascular phenomena is traditionally done by differential equations, but this is time consuming and unsuitable for most undergraduate medical students. As a result, quantitative thinking about time-dependent physiological phenomena is often not extensively dealt with in an undergraduate physiological course. However, basic concepts of steady and presteady state can be explained with relative simplicity, without the introduction of differential equation, with equivalent electronic circuits (EECs). We introduced undergraduate medical students to the concept of simulating cardiovascular phenomena with EECs. EEC simulations facilitate the understanding of simple or complex time-dependent cardiovascular physiological phenomena by stressing the analogies between EECs and physiological processes. Student perceptions on using EEC to simulate, study, and understand cardiovascular phenomena were documented over a 9-yr period, and the impact of the course on the students' knowledge of selected basic facts and concepts in cardiovascular physiology was evaluated over a 3-yr period. We conclude that EECs are a valuable tool for teaching cardiovascular physiology concepts and that EECs promote active learning.

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Section: How We Teachmentioning

confidence: 99%

“…Thus, the undergraduate medical student can easily manipulate the model and observe the results of simulations. EEC models of selected cardiovascular, respiratory, or renal physiological and pathophysiological states have been described in detail in previous publications (6,17,38,39,45,46,50).…”

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confidence: 99%

Teaching cardiovascular physiology with equivalent electronic circuits in a practically oriented teaching module

Ribarič

Kordaš

2011

Advances in Physiology Education

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“…Mitral and aortic valve are simulated by diode D1. Input to the left ventricle is slightly modified as published (Dolenšek et al, 2009). Contractility modulation is the same as described in Sever and coworkers (Sever et al, 2007); via negative feedback it can be increased from 1 to about 8 "units of contractility".…”

Section: Methodsmentioning

confidence: 99%

“…Results are expressed graphically as described (Sever et al, 2007;Dolenšek et al, 2009), as the time course of equivalent variables. Thus electrical variables voltage, current, resistance, capacitance and charge correspond to physiological variables pressure, blood flow, resistance, capacitance and volume (for details refer to Sever et al, 2007;Dolenšek et al, 2009 Note that negative and undulating ITP affects slightly almost all variables. To allow comparison before and after a disturbance occurs, the time course of variables are recorded at the same instant of the heart cycle, defined here as the height of inspiration.…”

Section: Methodsmentioning

confidence: 99%

“…Third, the mean arterial pressure wasin some conditions -reset from the normal to a higher operating level (simulating increased sympathetic tone). By using these approaches recently various clinical conditions were simulated: acute left ventricle failure (myocardial infarction), aortic stenosis and exercise in man with aortic stenosis (Sever et al, 2007), and consequences of aortic and of mitral regurgitation (Dolenšek et al, 2009). In present simulations it is attempted to extend both recent simulations quoted above.…”

Section: Introductionmentioning

confidence: 99%

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Analog Simulation of Aortic Stenosis

Sever¹,

Ribarič²,

Runovc³

et al. 2011

Aortic Stenosis - Etiology, Pathophysiology and Treatment

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Lumped-Parameter Circuit Platform for Simulating Typical Cases of Pulmonary Hypertensions from Point of Hemodynamics

Tang

Dai

Wang

et al. 2020

J. of Cardiovasc. Trans. Res.

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Pulmonary hypertension (PH) presents unusual hemodynamic states characterized by abnormal high blood pressure in pulmonary artery. The objective of this study is to simulate how the hemodynamics develops in typical PH cases without treatment. A lumped-parameter circuit platform of human circulation system is set up to simulate hemodynamic abnormalities of PH in different etiologies and pathogenesis. Four typical cases are considered, which are distal pulmonary artery stenosis, left ventricular diastolic dysfunction, ventricular septal defect, and mitral stenosis. The authors propose regulation laws for chambers and vessels to adapt the abnormal hemodynamic conditions for each PH case. The occurrence and development of each PH case are simulated over time using the lumped-parameter circuit platform. The blood pressure, blood flow, pressure-volume relations for chambers and vessels are numerically calculated for each case of PH progression. The model results could be a quite helpful to understand the hemodynamic mechanism of typical PHs.

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Analog simulation of aortic and of mitral regurgitation

Cited by 7 publications

References 11 publications

Teaching cardiovascular physiology with equivalent electronic circuits in a practically oriented teaching module

Teaching cardiovascular physiology with equivalent electronic circuits in a practically oriented teaching module

Analog Simulation of Aortic Stenosis

Lumped-Parameter Circuit Platform for Simulating Typical Cases of Pulmonary Hypertensions from Point of Hemodynamics

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