Analogues of Neuropeptide Y Containing β‐Aminocyclopropane Carboxylic Acids are the Shortest Linear Peptides That Are Selective for the Y₁ Receptor

Abstract

The antimony thin films were synthesized in ultra-high vacuum (base pressure: 4 î 10 À11 mbar) by evaporation of Sb 4 molecules from a resistance-heated effusive oven (temperature: 330 8C; deposition rate: 0.1 nm s À1 ; Sb: 99.9999 %, Johnson-Matthey). The layer thickness is given in monolayers of Sb atoms. The MoS 2 substrates were prepared by cleavage according to the procedure given in reference [13]. The AuSb 2 surface alloy was prepared starting from Au(111). [14] On this substrate the surface alloy AuSb 2 with the (100) orientation forms spontaneously, if less than one monolayer of antimony is deposited at room temperature. [15] The beetle-type STM [16] is located in an analysis chamber directly attached to the preparation chamber. [17] To increase image contrast, the STM data were electronically differentiated directly during acquisition. Therefore the STM images appear as if they are illuminated from the side.

Enantioselective synthesis of (−)-paeonilide

“…[29][30][31][32][33] This interesting moiety is also present in biologically active compounds, as natural and synthetic cyclopropanes are endowed with a large range of biological properties, such as enzyme inhibition, insecticidal, antifungal, herbicidal, antimicrobial, antibiotic, antibacterial, antitumor and antiviral activities. 34 The history of cyclopropanations of furans started already more than two decades ago.…”

Two Helical Conformations from a Single Foldamer Backbone: “Split Personality” in Short α/β‐Peptides

“…[4] Structural data suggest that these foldamers have a "split personality," simultaneously populating two different helical conformations. Both helices contain backbone C= O···HÀN hydrogen bonds with N!C directionality, but they differ in the sequential spacing between C = O and HÀN (i,i + 3 in one case, i,i + 4 in the other).…”

Identification of neuropeptide Y cleavage products in human blood to improve metabolic stability

“…26 Only antagonists have been reported to consist only of C-terminal segments 27,28 ; however, their internalization could not be shown so far. All analogs were synthesized with Pro at position 34 because this is known to lead to a loss of The most significant Y 1 -receptor preference was obtained ]NPY (1-35) in each case.…”

“…35 The enzymatic stability of Y 2 -receptor selective centrally truncated analogs was found to be significantly less than that of native NPY. Accordingly, we decided not to use any smaller reported analogs, e. g. NPY (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), although this analog has been shown to exhibit some agonistic properties at Y 2 -receptors as well. 36,37 In case of CF-[Ahx [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] ]NPY, which is a centrally truncated Y 2 receptor selective analog, [17][18][19] an enzymatic degradation product CF-[Ahx [5][6][7][8][9][10][11][12][13][14]…”