Analogues of SB-203207 as inhibitors of tRNA synthetases

Banwell, Martin G.; Crasto, Curtis F.; Easton, Christopher J.; Forrest, Andrew K.; Karoli, Tomislav; March, Darren R.; Mensah, Lucy; Nairn, Michael R.; O’Hanlon, Peter J.; Oldham, Mark D.; Yue, Weimin

doi:10.1016/s0960-894x(00)00456-x

Cited by 73 publications

(34 citation statements)

References 8 publications

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“…As in the two previous cases, a high loading of 1 was needed to obtain the corresponding amide product 24 in high yield. SB-203207 can also be accessed by acylation of the sulfonamide unit of naturally occurring altemicidin (26 in Scheme 8) [42]. In this context, the stereoselective synthesis of a key intermediate for altemicidin, i.e.…”

Section: Preparation Of Complex [Pth{(pme 2 O) 2 H}(pme 2 Oh)] Firstmentioning

confidence: 99%

Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

Cadierno

2015

Applied Sciences

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Abstract:The air-stable hydride-platinum(II) complex [PtH{(PMe2O)2H}(PMe2OH)], reported by Parkins and co-workers in 1995, is the most versatile catalyst currently available for the hydration of C≡N bonds. It features remarkable activity under relatively mild conditions and exceptionally high functional group compatibility, facts that have allowed the implementation of this complex in the synthesis of a large number of structurally complex, biologically active molecules and natural products. In this contribution, synthetic applications of the Parkins catalyst are reviewed.

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Section: Preparation Of Complex [Pth{(pme 2 O) 2 H}(pme 2 Oh)] Firstmentioning

confidence: 99%

Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

Cadierno

2015

Applied Sciences

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“…In recent years, N-(arylsulfonyl)-arylamides have received much attention as they constitute an important class of drugs for Alzheimer's disease (Hasegawa & Yamamoto, 2000), anti-bacterial inhibitors of tRNA synthetases (Banwell et al, 2000), antagonists for angiotensin II (Chang et al, 1994) and as leukotriene D4-receptors (Musser et al, 1990). Further, N-(arylsulfonyl)-arylamides are known as potent antitumour agents against a broad spectrum of human tumour xenografts (colon, lung, breast, ovary and prostate) in nude mice (Mader et al, 2005).…”

Section: Structure Descriptionmentioning

confidence: 99%

4-Iodo-N-(o-tolylsulfonyl)benzamide

Naveen¹,

Suresha²,

Sudha³

et al. 2017

IUCr Data

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The title compound, C14H12INO3S, crystallizes with two independent molecules (AandB) in the asymmetric unit. The dihedral angle between the two aryl rings is 83.1 (4)° in moleculeAand 79.8 (4)° in moleculeB. In the crystal, the two molecules are linked by a pair of N—H...O hydrogen bonds, forming anA–Bdimer with anR22(8) ring motif. The dimer is further strengthened by a pair of C—H...O hydrogen bonds with anR22(14) motif. Another pair of C—H...O interactions assembles these dimers along the diagonal of thebcplane, forming ribbons. Adjacent ribbons are connected by C—H...πarylinteractions between theAmolecules, and thus the overall supramolecular architecture is one-dimensional.

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“…A large number of novel N-acylated-sulfonamidessulfonamides molecules have been investigated for antibacterial activity 4 . They are also known as therapeutic agents for Alzheimer's disease 5 and antiproliferative agents 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Acylation of sulfonamides can also be achieved with concentrated H 2 SO 4 8 , Lewis acids 9 or heterogeneous solid acid 10 in acetonitrile under acidic conditions. Another attractive method based on using of palladium-catalyzed acylation of aryl with sulfonamides under microwave irradiation 11 .…”

Section: Introductionmentioning

confidence: 99%

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Bouasla¹,

Bechlem²,

Belhani³

et al. 2017

Orient. J. Chem

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A facile and versatile method for acylation of structurally diverse amines and sulfonamides under focused ultrasonic irradiation in catalyst-free and solvent-free conditions is reported. There are several advantages to this approach such as simple and easier workup conditions, small amount of time and high yielding. The acylation reaction was carried out with acetic anhydride. All structures of synthesized products have been identified by NMR and mass spectroscopy.

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Analogues of SB-203207 as inhibitors of tRNA synthetases

Cited by 73 publications

References 8 publications

Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

4-Iodo-N-(o-tolylsulfonyl)benzamide

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

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