1970
DOI: 10.1016/0014-5793(70)80483-5
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Analogy between in vivo and in vitro biological effect of chloramphenicol and its acetylated derivatives

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1972
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Cited by 5 publications
(4 citation statements)
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“…This is in agreement with the in vivo data obtained for this compound by the MIC determinations [5].…”
Section: Discussionsupporting
confidence: 82%
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“…This is in agreement with the in vivo data obtained for this compound by the MIC determinations [5].…”
Section: Discussionsupporting
confidence: 82%
“…In the presence of 1,3-diacctoxychloramphenicol or of the 1-monoacetoxyderivative, no inhibition is observed: the amount of labelled amino acid incorporated is comparable to that obtained in the con trol assay without antibiotic. Little but sig nificant inhibitory activity is found with 3-monoacetoxy-chloramphenicol; this result is confirmed by the minimal inhibitory con centration (MIC) determinations [5].…”
Section: Methodssupporting
confidence: 58%
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“…Our failure can be explained by a more recent crystallographic study conducted in E. coli ribosome [ 19 ]; the new orientation of CAM is rotated by 180°, thus directing the OH group in position 3 of CAM away from U2506 ( Figure 4 B). Noteworthy, CAM efficacy is decreased by mono-acetylation (compound 17 ) and nearly disappeared with di-acetylation (compound 18 ) [ 85 ].…”
Section: Modifications Of Cam To Obtain Antibacterials With Improvmentioning
confidence: 99%