Analyse électroencéphalographique intercritique des encéphalites à anticorps anti-récepteurs NMDA : étude de 10 cas

Jeannin-Mayer, Sophie; Rosenberg, Sarah; Convers, Philippe; Bicilli, Elodie; Antoine, Jean‐Christophe; Mazzola, Laure

doi:10.1016/j.neucli.2016.05.016

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“…It often showed a diffuse or focal non-specific slowing (up to 90% of cases) and sometimes epileptic abnormalities [19,31,48]. On the other hand, an "extreme delta brush (EDB)" pattern has been described only in anti NMDAr encephalitis, which is very suggestive, and even fast rhythms or slow rhythmic waves [15,35,47]. In our study population, the initial EEG was often pathological (76.7% of cases), often displaying the non-specific abnormalities described above [19].…”

Section: Discussionmentioning

confidence: 99%

Dysimmune Encephalitis: Clinical Study

Hakim¹,

Daoudi²

2023

JNNR

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Introduction: Autoimmune encephalitis is a new and little-known entity targeting CNS antigens. It often causes inflammatory limbic encephalitis, for which immunotherapy is effective. Objective: The main objective of the study is to determine the clinical and paraclinical characteristics of encephalitides associated with NMDAr, CASPR2 and LGI1 antibodies. Materials and methods: It are a descriptive, prospective and retrospective study, which started from January 2016 to December 2018. Results: Our cohort included 30 patients with a mean age of 44±18.05 years. The limbic encephalitis was acute in 73.3%. The patients presented mainly psychiatric and vigilance disorders, epileptic seizures, dysautonomia, and memory disorders. A temporal hyper signal (± extra limbic) was often found on MRI, with non-specific abnormalities in the EEG and an inflammatory CSF profile. FBDS, dyskinesias, and neuro myotonia were the discriminating signs. Neoplasia was found in 16.7% of the cases. Immunotherapy led to good results. Conclusion: This study aimed to know how to identify these entities in our country and establish an early and effective treatment for better outcomes. A study with large samples would be more beneficial.

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