Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review

Fu, Xiaorui; Shang, Yufeng; Zhang, Lei; Li, Ling; Li, Xin; Wang, Xinhua; Sun, Zhenchang; Zhang, Mingzhi

doi:10.3892/ol.2018.9447

Cited by 7 publications

(11 citation statements)

References 32 publications

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“…Differential diagnoses of lymphadenopathy associated with CML include infection (tuberculosis...), myeloid proliferation (myeloid sarcoma/chloroma), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL) B/T, and lymphoblastic lymphoma B/T-LBL [ 13 ]. The prognosis of blast crisis and EBC is very poor [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis

Benlachgar,

Masrar,

Haidouri

et al. 2023

Cureus

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Chronic myeloid leukemia (CML) with BCR-ABL1-positive cells is a myeloproliferative neoplasm (MPN) characterized by a chromosomal translocation t(9,22)(q34.1;q11.2), which results in the formation of a Philadelphia (Ph) chromosome containing the BCR-ABL1 fusion gene. Extramedullary blast crisis (EBC) associated with bcr/abl-positive CML is a rare initial presentation. Here, we present and discuss the case of a 51-year-old man who presented with a weight loss history, cervical swelling, and left-sided abdominal pain. He had a white blood cell count of 147,910/mm3. The blood smear study revealed myelemia in 23% and 8% of blast-like cells. The bone marrow aspiration and biopsy showed a richly cellularized sample; the megakaryocytes were present; the granular neutrophil line was at 89% with blasts at 1%. The cytogenetic analysis revealed a complex karyotype with the presence of a Philadelphia chromosome t (9, 22) (q34, q11) associated with additional cytogenetic abnormalities (ACA). Molecular analysis (PCR) detected a BCR::ABL1 (p210) rearrangement. At this point, a diagnosis of CML in the chronic phase was confirmed, but a cervical lymph node biopsy analysis revealed a bi-phenotypic B/T-lymphoblastic lymphoma (LBL) and expressed at fluorescent in situ hybridization (FISH) analysis BCR::ABL1 rearrangement. These findings were consistent with the diagnosis of a bi-phenotypic B/T extramedullary blast crisis associated with CML.

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Section: Discussionmentioning

confidence: 99%

“…In a retrospective case series of patients with bi-lineage myeloid and lymphoid neoplasms, hematopoietic stem cell transplantation (HSCT) resulted in a statistically significant advantage in overall survival [ 13 ]. Allo-SCT is associated with a high rate of transplantation-related mortality [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis

Benlachgar,

Masrar,

Haidouri

et al. 2023

Cureus

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“…There has been a case report of secondary malignancies in CML [ 7 ]. Fu et al [ 8 ] reported simultaneous diagnosis of T-LBL and BCR-ABL positive CML in two adult patients who were treated with imatinib and HYPER-CVAD chemotherapy. Simultaneous acute myeloid leukaemia (AML) and lymphoma has been reported in the literature and is more frequent than simultaneous CML and lymphoma [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

T lymphoblastic lymphoma with BCR-ABL negative chronic myeloid leukaemia: a novel association

Faizan¹,

Anwar²,

Ain³

et al. 2021

ecancer

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Lymphoblastic lymphoma and chronic myeloid leukaemia (CML) are two distinct neoplasms with different pathogenesis and clinical presentation. We hereby share a challenging case of a child presenting with fever, leucocytosis, generalised lymphadenopathy and massive splenomegaly. He was diagnosed as having novel association of concurrent T-lymphoblastic lymphoma diagnosed on cervical lymph node biopsy with BCR-ABL negative CML on bone marrow aspirate. The study of more such cases is needed for optimal patient management.

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“…Ils sont responsables du développement de tumeurs au niveau des organes lymphoïdes, notamment ganglionnaires, mais aussi de territoires non lymphoïdes (Cuenca et al, 2009). La coexistence d'une double prolifération maligne, myéloïde et lymphoïde et particulièrement lymphomateuse, est rare bien que décrite depuis quelques décennies (Martoïa et al, 1987;Doumouchel et al, 1983;Monoharan et al, 1981) et depuis quelques années plusieurs publications décrivent des hémopathies lymphoïdes diversement associées aux hémopathies myéloïdes surtout la LMC (Amy et al, 2018; Xiaorui Fu et al, 2018;Paolo et al, 2018;Smeeta Gajendra et al, 2016). Cette coexistence qu'elle soit spontanée ou non, simultanée ou séquentielle, elle évoque davantage une atteinte de la cellule souche hématopoïétique, se démasquant au niveau de deux lignées filles, qu'une banale coïncidence.…”

Section: Introductionunclassified

Coexistence D’un Lymphome Lymphocytique Et D’une Leucémie Myéloïde Chronique: A Propos De Deux Observations Au Togo

Padaro

Magnang

Layibo

et al. 2021

ESJ

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Les auteurs rapportent deux cas de lymphomes lymphocytiques associés à une leucémie myéloïde chronique (LMC) au Togo. La première association est une coexistence simultanée d’une LMC avec présence du transcrit de fusion bcr-abl chez une patiente de 32 ans, au stade myélocytaire chronique, avec une polyadénopathie ayant nécessité une biopsie ganglionnaire qui a conclu à un lymphome lymphocytique. Le deuxième cas est une succession à 6 ans 5 mois d’intervalle, chez un patient de 30 ans, d’une LMC avec présence du bcr-abl et d’un chromosome Philadelphie et d’un lymphome lymphocytique. Ces deux cas sont rapprochésdiachronique des des associations d’hémopathies myéloïdes et lymphoïdes, aiguës ou chroniques. Dide la chimiothérapie mais le diagnostic est parfois simultané ; implication des oncogènes cellulaires ; plus vraisemblablement anomalie clonale de la cellule souche hématopoïétique s’exprimant de façon séquentielle ou simultanée sur les deux lignées filles. A notre connaissance, il s’agit des premières descriptions en Afrique subsaharienne.fférentes hypothèses pathogéniques sont passées en revue : responsabilité This paper reported two cases of lymphocytic lymphoma associated with chronic myeloid leukemia (CML) in Togo. The first association is a simultaneous coexistence of a CML with the presence of the transcript bcr-abl, in a 32-year-old woman, at chronic myelocytic stage with polyadenopathy required and lymph node biopsy concluded for lymphocytic lymphoma. The second is the case of a 30-year-old man who developed a lymphocytic lymphoma after 6years and 5 months of following CML. These two cases are comparable to other associations of acute or chronic myeloid and lymphoid blood malignancies that was previously published. Several pathogenic hypothesis were reviewed which takes responsibility for chemotherapy. Nevertheless, the diagnosis is sometimes simultaneous with the involvement of cellular oncogenes. This is a more likely clonal abnormality of the stem cell sequentially or concomitantly expressed in the cells on both lineages. To the best of our knowledge, these are the first descriptions in South-Saharan Africa.

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Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review

Cited by 7 publications

References 32 publications

Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis

Bi-lineage B- and T-lymphoid Extramedullary Blast Crisis at an Initial Presentation of Chronic Myeloid Leukemia: A Case Report and Literature Review of Extramedullary Blast Crisis

T lymphoblastic lymphoma with BCR-ABL negative chronic myeloid leukaemia: a novel association

Coexistence D’un Lymphome Lymphocytique Et D’une Leucémie Myéloïde Chronique: A Propos De Deux Observations Au Togo

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