Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

Çelik, Ataç; Özçetin, Mustafa; Ateş, Ömer; Altunkaş, Fatih; Karaman, Kayıhan; Akar, İlker; İnce, İlker; Yalçın, Murat; Karayakalı, Metin; Ceyhan, Köksal; Koç, Fatih

doi:10.5152/balkanmedj.2015.151190

Cited by 8 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After removing duplicates and screening title and abstracts, 54 articles were subjected to the full‐text assessment and 12 articles were excluded due to the lack of detailed genotype distribution data. Finally, 37 articles 12‐14,16,24‐56 were included in the qualitative and quantitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…The IL‐6 gene is located on chromosome 7p21‐24 and comprises 5 introns and 6 exons 11 . Many SNPs in the IL‐6 gene related to CAD risk have been reported, including IL‐6 ‐174G/C, 12 IL‐6 ‐572C/G, 13 IL‐6 ‐597G/A, 14 IL‐6 ‐634C/G 15 and IL‐6 +2954G/C 16 ; however, some of them were not associated with CAD risk (IL6‐597G/A and +2954G/C) or only one study reported the increased risk of CAD (IL‐6‐634C/G). Among them, two common polymorphisms ( IL‐6 rs1800795 −174G/C and IL‐6 rs1800796 −572C/G) have been extensively investigated; however, the results were inconclusive.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

Lü

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Studies examining the associations between the interleukin‐6 (IL‐6) rs1800795 and rs1800796 gene polymorphisms and risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate the accurately determine role of these two polymorphisms in CAD risk. PubMed, Embase, VIP, Wan fang and China National Knowledge Infrastructure databases were searched. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The trial sequential analysis (TSA) was conducted, and bioinformatics tools were employed. A total of thirty‐seven articles were obtained. For the IL‐6 rs1800795 polymorphism, 9411 CAD patients and 3161 controls were included, 4720 patients with CAD, and 5000 controls were included for the IL‐6 rs1800796 polymorphism. In the pooled analysis, significant associations were only observed for the rs1800796 polymorphism (allelic: OR [95%CI] = 1.28 [1.13, 1.44], dominant: OR [95%CI] = 1.35 [1.17, 1.57], recessive: OR [95%CI] = 1.35 [1.18, 1.55], heterozygote: OR [95%CI] = 1.26 [1.15, 1.37], homozygote: OR [95%CI] = 1.62 [1.23, 2.13]). Significant associations were detected in the Asian and Mongoloid populations and ‘more than 500’ subgroup for the rs1800795 polymorphism. TSA confirmed the true‐positive results for the rs1800796 polymorphism. The bioinformatics analysis showed that the two polymorphisms played important roles in the gene transcription. The IL‐6 rs1800796 polymorphism is associated with an increased susceptibility to CAD and is a risk factor for CAD. The IL‐6 rs1800795 polymorphism is associated with an increased risk of CAD in Asians, particularly in Chinese, and a decreased risk of CAD in an African population is remarkably observed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

Lü

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…In a study conducted by Jang et al in 2008, 572 G / C polymorphism in Korean CAD patients was found to be significantly associated with inflammatory variables [13,29]. Celik et al showed that in a study conducted in 2015, there was a significant relationship between the IL-6 572 G / C gene polymorphism (in the presence of C allele) and adolescents having a parental history of premature CAD [1]. A Meta-analysis study reported that in the Asian population, the IL-6 C-572 G gene polymorphism was indicated to be correlated with CAD susceptibility and the carriers of -572 G allele might be predisposed to CAD risk [30].…”

Section: Bp 101 Bp 62 Bp Mmentioning

confidence: 99%

“…Coronary artery disease (CAD) in the community is known as the main cause of mortality and morbidity, as well as a consequence of the development of atherosclerosis in the coronary arteries [1,2]. CAD is a very complex genetic based disease that is affected by genetic influences and environmental factors [3].…”

Section: Introductionmentioning

confidence: 99%

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Güler¹

2019

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology

View full text Add to dashboard Cite

The most important characteristic of coronary artery disease, which is one of the most prevalent and most important healthy problem today, is that it can lead to life-threatening myocardial infarction in advanced stages. It is more important to take protective preventions by knowing the risk factors that cause the disease rather than the treatment of this disease. This study included determining the frequency of interleukin-6 (IL-6) gene 572 G / C polymorphism in individuals with coronary artery disease (CAD) and determining the role of that polymorphism in the development of CAD. In the current study, DNAs were isolated from the blood of a total of 185 individuals (103 coronary patients and 82 controls) by the salt method. Genotypes of IL-6 572 G / C polymorphism were detected by using molecular techniques (PCR, RFLP and electrophoresis) from these isolated DNAs. The results obtained were evaluated statistically. According to these results, the frequencies of 572 G / C genotype were 83% for GC, 17% for GC, 0% for CC in control subjects for CAD; whereas in patients, GG 72%, GC 28% and CC 0% were detected in the patients. No statistically considerable difference was determined between control and patient groups in terms of frequency of 572 G / C alleles and the GG genotype was significantly higher in the patient group. Based on the results of the currently study, we can say that there is no correlation between coronary artery disease and IL-6 572 G / C polymorphism frequency.

show abstract

“…A recent Turkish study focused on biomarkers of atherosclerosis in young people with a family history of coronaropathy, including CRP and interleukin-6 ( 5 ). It was worth noting that carotid intima-media thickness was not useful to evaluate subclinical atherosclerosis among the Turkish adolescent group ( 5 ). The patient herein reported kidney dysfunction and high CRP, often related to secondary hyperparathyroidism with bone mobilisation of calcium and multiple arterial calcifications.…”

mentioning

confidence: 99%

Abdominal Challenging Image in an Elderly Woman

Fe²

2017

Balkan Med J

View full text Add to dashboard Cite

Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

Cited by 8 publications

References 27 publications

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Abdominal Challenging Image in an Elderly Woman

Contact Info

Product

Resources

About