Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins
Alexander W. Lehr,
Kathryn F. McDaniel,
Katherine W. Roche
Abstract:Background/Objectives: Neuroligins (NLGNs) are postsynaptic adhesion molecules critical for neuronal development that are highly associated with autism spectrum disorder (ASD). Here, we provide an overview of the literature on NLGN rare variants. In addition, we introduce a new approach to analyze human variation within NLGN genes to identify sensitive regions that have an increased frequency of ASD-associated variants to better understand NLGN function. Methods: To identify critical protein subdomains within … Show more
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