Analyses of the 2019 Nobel Prize in Physiology or Medicine: Molecular Machinery for Cellular Oxygen Level Response

Helical sulfonyl-γ-AApeptides for the inhibition of HIV-1 fusion and HIF-1α signaling

“…49–51 The elucidation of HIF's mechanism to sense and adapt the cellular response to oxygen levels was awarded the Nobel Prize in 2019. 52 Notably, HIF-1 induces the transcription of more than 100 genes involved in different biological processes such as metabolism, anti-apoptosis and angiogenesis. HIF-1 is a heterodimer of an α and a β subunit, especially HIF-1α acts as a primary regulator to activate the hypoxic response.…”

“…Helix B and helix C were investigated to possess key residues and significantly influence the transcriptional activities of HIF-1α. 49–55 Inspired by this hot-spot PPI binding pocket, we extended an effort to mimic helix C using l -sulfonyl-γ-AApeptide inhibiting HIF-1α/p300 PPI and HIF-1α signaling pathways. 53–59…”

Potential therapeutic effects of Ivermectin in COVID-19

“…34 HIF-1α is a subunit of a heterodimeric transcription factor that responds to the reduction of oxygen levels in the cellular environment or hypoxia, and adapts the cellular response to oxygen availability. [98][99][100] Through the virus-mediated activation of HIF-1α, the inflammatory response is exacerbated in severe cases of COVID-19 disease. The targets of HIF-1α are all involved in the activation of pro-inflammatory cytokine expression and the subsequent inflammation.…”