2021
DOI: 10.1101/2021.08.27.457967
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Analyses of the 5’ Ends of Escherichia coli ORFs

Abstract: Sequence biases at 5-prime ends of coding sequences differ from those of the remainder of ORFs, reflecting differences in function. Internal sequence biases promote translational efficiency by several mechanisms including correlating codon usage and tRNA concentration. However, the early region may also facilitate translational initiation, establishment of the reading frame, and polypeptide processing. Here we examine the beginnings of the ORFs of an Escherichia coli K12 reference genome. The results exten… Show more

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