The slim-floor building system is attractive to constructors and architects due to the integration of steel beam in the overall height of the floor, which leads to additional floor-to-floor space, used mostly in acquiring additional storeys. The concrete slab offers natural fire protection for steel beams, while the use of novel corrugated steel sheeting reduces the concrete volume, and replaces the secondary beams (for usual spans of steel structures). Currently the slim-floor solutions are applied in non-seismic regions, and there are few studies that consider continuous or semi-continuous fixing of slim-floor beams. The present study was performed with the aim to develop reliable end-plate bolted connections for slim-floor beams, capable of being applicable to buildings located in areas with seismic hazard. It is based on numerical finite element analysis, developed in two stages. In a first stage, a finite element numerical model was calibrated based on a four point bending test of a slim-floor beam. Further, a case study was analysed for the investigation of beam-to-column joints with moment resisting connections between slim-floor beams and columns. The response was investigated considering both sagging and hogging bending moment. The results are analysed in terms of moment-rotation curve characteristics and failure mechanism.