The choice of the appropriate toll collection system is a very important decision because it requires significant investment and a poor decision regarding the choice of toll collection system can lead to major economic, environmental, and social problems for both present and future generations. This study aims to propose a methodological framework for decision support in selecting toll collection systems based on comprehensive multi-criteria analysis. The selection of the most effective toll collection system was performed from financial and economic aspects, using the AHP method. The study included 9 different toll collection technologies: DSRC with barriers, DSRC MLFF, RFID, GNSS/CN, ACM, ANPR, SmartCard, Smartphone, and vignettes. By the defined problem and specific priorities, it was found that GNSS/CN (0.174) is the best toll-collection technology. RFID toll collection technology (0.169) and DSRC MLFF technology (0.163) are equally good, while automated toll payment booths (0.040) are at the bottom. The obtained results can help decision-makers when choosing the most profitable toll-collection technology from the financial and economic aspects.