Analysis and biological activities of anthocyanins

Kong, Jin-Ming; Chia, Lian Sai; Goh, Ngoh-Khang; Chia, T. T.; Brouillard, Raymond

doi:10.1016/s0031-9422(03)00438-2

Cited by 1,392 publications

(983 citation statements)

References 53 publications

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“…1) [2]. The most common sugar components of anthocyanins are glucose, galactose and arabinose, usually conjugated to the C3 hydroxyl group in the anthocyanidin C ring.…”

Section: Pharmaceutical Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset

Teller

Cai

et al. 2009

Cancer Chemother Pharmacol

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Anthocyanins, plant pigments in fruits and berries, have been shown to delay cancer development in rodent models of carcinogenesis, especially those of the colorectal tract. Anthocyanins and anthocyanidins, their aglycons, especially cyanidin and delphinidin, have been subjected to extensive mechanistic studies. In cells in vitro, both glycosides and aglycons engage an array of anti-oncogenic mechanisms including anti-proliferation, induction of apoptosis and inhibition of activities of oncogenic transcription factors and protein tyrosine kinases. Anthocyanins and anthocyanidins exist as four isomers, interconversion between which depends on pH, temperature and access of light. Anthocyanidins are much more prone to avid chemical decomposition than the glycosides, and they only survive for minutes in the biophase. These pharmaceutical issues are very important determinants of the suitability of these flavonoids for potential development as cancer chemopreventive drugs, and they have hitherto not received adequate attention. In the light of their robust cancer chemopreventive efficacy in experimental models and their superior stability as compared to that of the aglycons, the anthocyanins seem much more suitable for further drug development than their anthocyanidin counterparts.

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“…1) [2]. The most common sugar components of anthocyanins are glucose, galactose and arabinose, usually conjugated to the C3 hydroxyl group in the anthocyanidin C ring.…”

Section: Pharmaceutical Propertiesmentioning

confidence: 99%

“…The most common sugar components of anthocyanins are glucose, galactose and arabinose, usually conjugated to the C3 hydroxyl group in the anthocyanidin C ring. To date, in excess of 400 naturally occurring anthocyanins have been identified [2].…”

Section: Pharmaceutical Propertiesmentioning

confidence: 99%

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset

Teller

Cai

et al. 2009

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

show abstract

“…Anthocyanins, from the flavonoids family, are found mainly in berries and have high antioxidant activity, which plays a vital role in the prevention of neuronal and cardiovascular illnesses, diabetes and cancer, among others (7).…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of Different Enriched Phenolic Extracts of Wild Fruits from Northeastern Portugal: A Comparative Study

Guimarães

Barros

Calhelha

et al. 2013

Plant Foods Hum Nutr

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Arbutus unedo, Prunus spinosa, Rosa micrantha and Rosa canina are good sources of phenolic compounds, including anthocyanins. These compounds have potent antioxidant properties, which have been related to anticancer activity. Herein, the in vitro antioxidant and antitumor properties of enriched phenolic extracts (nonanthocyanin phenolic compounds enriched extract-PE and anthocyanins enriched extract-AE) of the mentioned wild fruits were evaluated and compared. PE gave higher bioactive properties than the corresponding AE. It was observed a high capacity of A.unedo phenolic extract to inhibit lipid peroxidation in animal brain homogenates (EC 50 = 7.21 µg/mL), as also a high antitumor potential against NCI-H460 human cell line (non-small lung cancer; GI 50 = 37.68 µg/mL), which could be related to the presence of galloyl derivatives (exclusively found in this species). The bioactivity of the studied wild fruits proved to be more related to the phenolic compounds profile than to the amounts present in each extract, and could be considered in the design of new formulations of dietary supplements or functional foods.

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“…We have also reported that capsules containing an anthocyanin mixture can inhibit platelet granule secretion in the plasma of patients with hypercholesterolaemia (11). However, the underlying biological effects and mechanisms of action of the attenuation of platelet granule release by Cy-3-g, which is the most common anthocyanin with a glycoside, have not been well elucidated in vivo (15). The objective of this study was to determine the effects of the anthocyanin Cy-3-g, purified from black rice, on gel-filtered platelets in mice fed high-fat diets.…”

mentioning

confidence: 99%

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

ZHOU

Deng

Chen

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-b1 in gel-filtered platelets, in addition to attenuating serum PF4 and b-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

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Analysis and biological activities of anthocyanins

Cited by 1,392 publications

References 53 publications

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Bioactivity of Different Enriched Phenolic Extracts of Wild Fruits from Northeastern Portugal: A Comparative Study

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

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