The reliability of marine propulsion systems depends on the reliability of several sub-systems of a diesel engine. The scavenge air system is one of the crucial sub-systems of the marine engine with a turbocharger as an essential component. In this paper, the failures of a turbocharger are analyzed through the fault tree analysis (FTA) method to estimate the reliability of the system and to predict the cause of failures. The quantitative method is used for assessing the probability of faults occurring in the turbocharger system. The main failures of a scavenge air sub-system, such as air filter blockage, compressor fouling, turbine fouling (exhaust side), cooler tube blockage and cooler air side blockage, are simulated on a Wärtsilä-Transas engine simulator for a marine two-stroke diesel engine. The results obtained through the simulation can provide improvement in the maintenance plan, reliability of the propulsion system and optimization of turbocharger operation during exploitation time.