When looking at maps of land use land cover (LULC) change, often derived from satellite imagery, China's increasing urban construction and decreasing cultivated land area can be identified. Using the middle reaches of the Yellow River Basin in China as the case study, the present work focuses on (i) identifying historical LULC change in the period 1995–2020; (ii) estimating LULC in the next ten years, combining Geographical Information Systems (GIS) with Markov model. Landsat 5/8 images were combined with field evidence to map LULC in three reference years (1995, 2005, 2015and2020), while the Markov model was applied to forecast LULC in 2025, and 2030.The LULC of the middle reaches of the Yellow River Basin was classified into six classes: forest, grassland, wetland, cultivated land, construction land and unused land. The results show that over the past 25 years, cultivated land and forest land have decreased by 8,600 km2 and 6,400 km2, respectively, while construction land has increased by 7,500 km2, mainly due to increased urbanization and industrialization. In fact, during the simulated 2020–2030 period, cultivated land and forest land will continue to decrease, while construction land and grassland will increase. It is worth noting that the reduction of forest land will lead to increased soil erosion, while the reduction of cultivated land will lead to food security problems. The study points out that there is an urgent need for response measures in the region to ensure the sustainability of people and nature.