This work presents a self-timed resonant highvoltage (HV) dc-dc converter in HV CMOS silicon-on-insulator (SOI) with a one-step conversion from 100-325 V input down to a 3.3-10 V output, optimized for applications below 500 mW, such as IoT, smart home, and e-mobility. Unlike bulky power modules, the HV converter is fully integrated, including an on-chip power stage, with only one external inductor (10 µH) and capacitor (470 nF). It reaches a high power density of 752 mW/cm 3 , an overall peak efficiency as high as 81%, and a light-load efficiency of 73.2% at 5 V and 50 mW output. HV loss-reduction techniques are presented and experimentally confirmed to offer an efficiency improvement of more than 32%. Integrated HV insulated gate bipolar transistors (IGBTs) are discussed and implemented as an attractive alternative to conventional integrated HV power switches, resulting in ∼20% smaller area at lower losses.