Analysis for Steroid Production of a Sertoli-Leydig Cell Tumor

Virilizing tumors of the ovary: imaging features

“…This appearance may be difficult to separate from a corpus luteum, although these patients would be expected to have fewer corpora lutea because of the high frequency of amenorrhea. Sertoli-Leydig cell tumors also tend to be solid but show a greater variety of cystic and solid composition 13,14 . Imaging studies are also frequently reported for Sertoli-Leydig and steroid cell tumors as negative 7±9 or showing nonspecific enlargement 15,16 .…”

Sertoli‐Leydig cell tumor of the ovary: Analysis of a single institution database

“…A review of the published work reveals that the majority of women present with features of viril-ization (50 to 85%), such as anovulation, oligomenorrhea, amenorrhea, facial hair growth, hoarseness of voice and enlargement of the clitoris. 8,9,11,12 Very rarely, these tumors can exhibit both androgenic and estrogenic function, 13,14 as occurred in one patient in our study who was diagnosed to have associated endometrial malignancy. At the time of initial presentation more that 95% of these tumors are generally confined to one ovary 1,9,10,15 and only about 2% are said to be bilateral; only five cases of bilateralism have been noted in the published work.…”