Analysis of 1,500 Kidney Transplantations at Sungkyunkwan University

Hong, J. W.; Shin, Min Jae; Moon, Hyung‐In; Lee, Sanghoon; Park, Jae Berm; Kwon, Choon Hyuck David; Lee, Suk-Koo; Kim, Jong Man

doi:10.4285/jkstn.2014.28.1.25

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Ganciclovir was indicated for Cytomegalovirus (CMV)-seronegative recipients with a seropositive donor or ATG induction. Since 2000, preemptive ganciclovir therapy is performed for CMV antigenemia titers ≥50/4 × 10 5 leukocytes with biweekly CMV screening within 3 months after KT and when a CMV infection is suspected [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Invasive Fungal Diseases in Kidney Transplant Recipients: Risk Factors for Mortality

Seok

Huh

Cho

et al. 2020

JCM

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Background: Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. Methods: A 1:2 retrospective case-control study was performed in an experienced single center in the Republic of Korea. We reviewed the electronic medical records of patients with IFD after KT between February 1995 and March 2015. Results: Of 1963 kidney transplant recipients, 48 (2.5%) were diagnosed with IFD. The median interval from KT to IFD diagnosis was 172 days. Invasive aspergillosis (IA) was the most common, followed by invasive candidiasis (IC). Diabetes mellitus (DM) (odds ratio (OR) 3.72, 95% confidence interval (CI) 1.34–10.31, p = 0.011) and acute rejection (OR 3.41, 95% CI 1.41–8.21, p = 0.006) were associated with IFD development. In the subgroup analyses, concomitant bacterial infection was associated with IC development (OR 20.10, 95% CI 3.60–112.08, p = 0.001), and delayed graft function was associated with IA occurrence (OR 10.60, 95% CI 1.05–106.84, p = 0.045). The 12-week mortality rate in all patients was 50.0%. Mortality rates were significantly higher in older patients (adjusted hazard ratio (aHR) 1.06, 95% CI 1.02–1.11, p = 0.004), or those with DM (aHR 2.61, 95% CI 1.02–6.68, p = 0.044), deceased donor transplantation (aHR 2.68, 95% CI 1.03–6.95, p = 0.043), lymphocyte-depleting antibody usage (aHR 0.26, 95% CI 0.08–0.80, p = 0.019), acute rejection (aHR 0.38, 95% CI 0.15–0.97, p = 0.044), and concomitant bacterial infection (aHR 8.76, 95% CI 1.62–47.51, p = 0.012). Conclusions: A total of 50% of IFD cases occurred six months or later after transplantation. The IFD-related mortality rate was high in kidney transplant recipients despite the low incidence. DM and acute rejection were associated with high mortality, as well as IFD development. As old age, deceased donor transplantation, lymphocyte-depleting antibody usage, and concomitant bacterial infection are risk factors for IFD-related mortality, efforts for its early diagnosis and appropriate treatment are required.

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Section: Methodsmentioning

confidence: 99%

Invasive Fungal Diseases in Kidney Transplant Recipients: Risk Factors for Mortality

Seok

Huh

Cho

et al. 2020

JCM

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“…Prior reports on clinical outcomes of kidney transplantation had mostly been published by large-volume centers that had started kidney transplantation before the turn of the millennium. In addition, most of these reports were published in the early 2000s [ 8 - 10 ]. Since there have been many updates in the field of transplantation, clinical outcomes from a medium-sized center that has recently started kidney transplantation can be noteworthy, although not entirely new.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study

Koh

Koo

Shin

et al. 2020

Korean Journal of Transplantation

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Background: Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has increased rapidly as more centers are implementing a transplantation program. The objective of this study was to determine clinical outcomes of the first 300 consecutive cases of KT in a single center. Methods: Clinical data of 300 cases of KT at Seoul National University Bundang Hospital from January 2004 to March 2018 were obtained from a prospectively collected database and retrospectively reviewed. Results: The mean age of patients was 47.7±12.9 years, and 59% of patients were male. There were 225 living donors and 75 deceased donors. A total of 42 cases were from ABO-incompatible donors. During a mean follow-up of 68.6±43.5 months, 38 patients (12.7%) experienced rejection. The most common cause was acute T-cell mediated rejection (9.0%). Eighteen patients experienced graft loss. One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively. One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively. Multivariate analysis revealed that graft weight-to-recipient weight ratio and rejection were significant factors affecting graft survival. Conclusions: This single-center review demonstrates clinical outcomes comparable to other major centers. Such good outcomes were obtained by good patient selection, dedicated transplant physicians, and adequate use of immunosuppressive therapy.

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Clinical Outcomes and Contributors in Contemporary Kidney Transplantation: Single Center Experience

Ahn

Park

et al. 2017

Korean J Transplant

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Analysis of 1,500 Kidney Transplantations at Sungkyunkwan University

Cited by 3 publications

References 19 publications

Invasive Fungal Diseases in Kidney Transplant Recipients: Risk Factors for Mortality

Invasive Fungal Diseases in Kidney Transplant Recipients: Risk Factors for Mortality

Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study

Clinical Outcomes and Contributors in Contemporary Kidney Transplantation: Single Center Experience

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