Analysis of 31 families with an apparently autosomal-dominant transmission of migraine with aura in the nuclear family

Abstract

We analyzed 31 families selected for an apparently autosomal-dominant mode of inheritance of migraine with aura (MA) in the nuclear family. The nuclear families were expanded with first- and second-degree relatives. All interviews were made by physicians experienced in headache diagnoses. The criteria of the International Headache Society were used. The population relative risk among children in nuclear families was similar to the estimated population relative risk of MA assuming an autosomal-dominant mode of inheritance. The population relative risk tended to decrease among first-degree relatives outside nuclear families and further among second-degree relatives. Both first- and second-degree relatives outside the nuclear families had a statistically significant lower risk of MA than expected. Thus, autosomal-dominant inheritance with or without reduced penetrance was unlikely. Autosomal-recessive inheritance was unlikely because of the unequal sex distribution. Other modes of inheritance were considered as well. Mitochondrial and X-linked inheritance were excluded because of paternal transmission. The female preponderance was too low to explain sex-influenced inheritance. We conclude that MA most likely has a multifactorial inheritance even in high-risk families with MA.

Replication and meta‐analysis of common variants identifies a genome‐wide significant locus in migraine

“…Subsequent to the replication study, we performed a meta-analysis combining the discovery study with all follow-up studies, and finally conducted a genotype-phenotype association analysis using the Danish sample to assess the impact of these susceptibility loci on the migraine phenotype. [16]. The patients were diagnosed using a validated semi-structured telephone interview [17][18][19][20] performed by trained physicians or trained senior medical students.…”

Migrânea com afasia: relato de uma família

“…O caráter genético da migrânea é bem reconhecido 3,4 , contudo o modo de herança constitui ainda um tópico de controvérsia, sendo que vários modos de transmissão genética têm sido propostos e incluem formas autossômicas dominantes, autossômicas recessivas ou multifatoriais [5][6][7] . Heterogeneidade genética é provavelmente a melhor explicação para a diversidade destas observações.…”

Migraine as a sex-conditioned inherited disorder: evidences from China and the world

“…Such resperpine-induced headaches could be prevented by methysergid (5-HT 2 receptor antagonist) [17] . On the other hand, Ferrari [18] Hanington [19] showed that platelet MAO levels increased as age increases, which could be an explanation of age-associated self-limitation of migraine attacks. Based on the fact that 5-HT gradually decreases after the climacteric, pharmacologic agents of 5-HT receptor agonists, such as eletriptan (a 5-HT1B/1D receptor agonist), are used to treat migraine.…”

“…In an elegant study, Ulrich et al analyzed 31 MA families and found that both first and second-degree relatives outside the nuclear families were at significant lower risk of MA than expected [19] . Their results suggest that AD inheritance with or without reduced penetrance was unlikely, AR model was also unlikely because of the unequal sex distribution, mitochondrial and the X-linked transmissions were not possible, and female preponderance was too low to explain a sex-influenced inheritance.…”