Analysis of 81 pesticides and metabolite residues in fruits and vegetables by diatomaceous earth column extraction and LC/MS/MS determination

Tseng, Sheng-Hong; Liu, Chin-Cheng; Lin, Yu-Ju; Chen, Hsin-Chih; Su, Shu-Chu; Chou, Hsiu-Kuan; Chou, Shin-Shou; Shih, Daniel Yang-Chih

doi:10.38212/2224-6614.2586

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…The SAM calibration curves of the recovered standard enable the determination of the intersection of a straight line with the x -axis, which is the value used for calculation of the targeted analyte concentration. Additionally, the influence of interferences on the results is eliminated by applying chromatography as a separation method [ 41 , 42 , 43 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Makuch-Kocka

Andres-Mach

Zagaja

et al. 2021

IJMS

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About 70 million people suffer from epilepsy—a chronic neurodegenerative disease. In most cases, the cause of the disease is unknown, but epilepsy can also develop as the result of a stroke, trauma to the brain, or the use of psychotropic substances. The treatment of epilepsy is mainly based on the administration of anticonvulsants, which the patient must most often use throughout their life. Despite significant progress in research on antiepileptic drugs, about 30% of patients still have drug-resistant epilepsy, which is insensitive to pharmacotherapy used so far. In our recent studies, we have shown that 4-alkyl-5-aryl-1,2,4-triazole-3-thiones act on the voltage-gated sodium channels and exhibit anticonvulsant activity in an MES (maximal electroshock-induced seizure) and 6Hz test in mice. Previous studies have shown their beneficial toxic and pharmacological profile, but their effect on a living organism during chronic use is still unknown. In the presented study, on the basis of the previously conducted tests and the PAMPA (parallel artificial membrane permeability assay) BBB (blood–brain barrier) test, we selected one 1,2,4-triazole-3-thione derivative—TP-315—for further studies aimed at assessing the impact of its chronic use on a living organism. After long-term administration of TP-315 to Albino Swiss mice, its effect on the functional parameters of internal organs was assessed by performing biochemical, morphological, and histopathological examinations. It was also determined whether the tested compound inhibits selected isoforms of the CYP450 enzyme system. On the basis of the conducted tests, it was found that TP-315 does not show nephrotoxic nor hepatotoxic effects and does not cause changes in hematological parameters. In vitro tests showed that TP-315 did not inhibit CYP2B6, CYP2D6, CYP3A4, or CYP3A5 enzymes at the concentration found in the serum of mice subjected to long-term exposure to this compound.

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Section: Resultsmentioning

confidence: 99%

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Makuch-Kocka

Andres-Mach

Zagaja

et al. 2021

IJMS

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“…Ultimately, these pesticide residues enter the human food chain and harm them (Saminathan et al 2019;Srivastava et al 2019).Various studies reported the presence of pesticides in our food. A similar study from Uganda reported that 58 pesticide residues were detected in fruits and vegetables (Omwenga et Tseng et al 2009). Because pesticides have enormous properties and toxicological effects on consumers' health.…”

Section: Introductionmentioning

confidence: 93%

Quantitation of Pesticides in 89 Rice Samples by Liquid Chromatography– Mass Spectrometry: Analysis of Delhi NCR

Temak,

Kapahi,

Rani

et al. 2024

Preprint

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Aim: To study the quantification of pesticides in 89 rice samples using liquid chromatography–mass spectrometry. Introduction: Monitoring pesticide residue in food matrices at very low concentrations is challenging work for an analyst and requires a valuable analytical technique. Material and Methods: In the current study, the dispersive solid– liquid extraction method was employed for quantification of different pesticides by liquid chromatography with tandem mass spectrometry (LC-MS/MS) electrospray ionization (ESI) (with a minimum run time of 10 minutes). Results: Twenty-two molecules were identified in the eighty-nine samples collected from different locations in the Delhi NCR region. Of these, eight samples were found to be contaminated with pesticide residues such as clothianidin (avg.conc. of 0.063 mg/kg), imidacloprid (avg. conc. of 0.064 mg/kg), thiamethoxam (avg. conc. 0.051 mg/kg), and tricyclazole (avg. conc. 0.044 mg/kg). Clothianidin and imidacloprid were found to be below the maximum residual limit (MRL) value, whereas thiamethoxam and tricyclazole were found to be above the MRL values as per the EU Guidelines. Conclusion: The limit of detection (LOD) and limit of quantification (LOQ) were 0.0025 and 0.005 mg/kg, respectively. The mean recovery was found to be within the range of 70-120% as per the SANTE 11312 guideline.

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“…Fast extraction times, decreased solvent use, and improved extraction efficiency are all hallmarks of MAE. In chlorantraniliprole analysis, it is used to increase extraction yields and decrease analysis time, both of which are very helpful when dealing with difficult sample matrices [40]. Different kinds of samples provide unique obstacles for pesticide residue analysis, and different preparation and extraction methods may be used to successfully isolate chlorantraniliprole and its metabolites from complex environmental matrices.…”

Section: A Solid-phase Extraction (Spe)mentioning

confidence: 99%

“…Available online at: https://jazindia.com -1388 -Chlorantraniliprole, once absorbed by the roots, is carried throughout the plant through the xylem and phloem, the two primary vascular tissues [58][59][60][61][62][63][64].…”

Section: Innovative Approaches For Characterizing Chlorantraniliprole...mentioning

confidence: 99%

Innovative Approaches for Characterizing Chlorantraniliprole and Its Metabolites in Soil, Water and Plants

Rakesh,

Inani

2023

J. Adv. Zool.

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The environmental effects and possible hazards of chlorantraniliprole, a frequently used insecticide, have recently come to the forefront. This article provides an in-depth look at novel methods for characterising chlorantraniliprole and its metabolites in soil, water, and plants. Various analytical procedures are covered in depth, including chromatographic methods, mass spectrometry, capillary electrophoresis, immunoassay-based procedures, and spectroscopic procedures. The difficulties and restrictions of chlorantraniliprole analysis, as well as its advantages, are discussed in length, along with sample preparation and extraction methods. The essay finishes by looking forward to several promising avenues of research and development, such as novel approaches, omics integration, and environmentally friendly analytic approaches. These findings aid in the advancement of chlorantraniliprole knowledge and open the path for more ecologically responsible pesticide application.

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Analysis of 81 pesticides and metabolite residues in fruits and vegetables by diatomaceous earth column extraction and LC/MS/MS determination

Cited by 4 publications

References 6 publications

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Quantitation of Pesticides in 89 Rice Samples by Liquid Chromatography– Mass Spectrometry: Analysis of Delhi NCR

Innovative Approaches for Characterizing Chlorantraniliprole and Its Metabolites in Soil, Water and Plants

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