Analysis of 825C/T Polymorphism of G Proteinβ3 Subunit in Obese/Diabetic Japanese

Ohshiro, Yuzuru; Ueda, Keiko; Wakasaki, Hisao; Takasu, Nobuyuki; Nanjo, Kishio

doi:10.1006/bbrc.2001.5450

Cited by 17 publications

(19 citation statements)

References 17 publications

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“…3,10,16 No associations have been found in other German and Spanish, as well as Polish, Australian, and Finnish subjects. 8,[13][14][15]17 In Japanese subjects, obesity has not been found, 4,24,27,28 and our result concur.…”

Section: Discussionsupporting

confidence: 83%

“…Almost the same frequency as previously reported in Japanese subjects (0.46 -0.59). 4,[22][23][24][25][26][27][28] The frequency varies to some extent among other races: in America Indians, 0.11 -0.33; in Caucasians, 0.21 -0.38; in Mongolians 0.42 -0.52; and in black Africans, 0.65 -0.91. 3 G protein activation is enhanced in immortalized lymphoblasts from German patients with essential hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…3 The roles of the 825T allele in hypertension, obesity, hyperlipidemia, diabetes, and diabetic complications have been controversial in Caucasians 2,3,5-21 and Japanese. [22][23][24][25][26][27][28] Thus, we investigated how this genetic polymorphism in the GNB3 is associated with hypertension, obesity, hyperlipidemia, diabetic complications, and diabetic therapies among Japanese.…”

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confidence: 99%

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Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

et al. 2007

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

et al. 2007

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“…Due to their pivotal function in many cell types, variation in the genes encoding the subunits of G proteins has the potential to play a role in numerous clinical conditions. Specifically, investigators have studied possible associations of the frequent substitution of a C with a T nucleotide at position 825 in exon 10 in the gene encoding the G protein β3 subunit (GNB3), resulting in the silent Ser275Ser polymorphism, with hypertension [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and related cardiovascular phenotypes [16][17][18][19][20][21][22], and with obesity [22][23][24][25], psychological syndromes [26][27][28], type 1 diabetes complications (nephropathy, retinopathy and neuropathy) [29,30], type 2 diabetes [13,22,31,32], cancer [33] and various immunological responses [34]. The 825C>T polymorphism is associated with the occurrence of a splice variant with an in-frame deletion of 41 amino acids (from exon 9) including the fourth of seven Trp-Asp repeats, each consisting of approximately 40 highly conserved amino acids, which normally form a β-propeller peptide structure [1].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, data from other studies support this notion, even though there are some conflicting results [12,[22][23][24][42][43][44]. Likewise, interindividual differences in BMI may also account for the observation that type 2 diabetic patients carrying the T allele had significantly improved insulin sensitivity compared with homozygous carriers of the C allele following an intervention-optimisation protocol [45].…”

Section: Introductionmentioning

confidence: 99%

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

et al. 2005

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Aims/hypothesis: The 825C>T polymorphism in the gene encoding the G protein β3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome. Materials and methods: The GNB3 825C>T polymorphism was genotyped in 7,518 white Danish subjects using mass spectrometry analysis of PCR products. Case-control studies were undertaken for obesity, hypertension, type 2 diabetes and the metabolic syndrome, and a meta-analysis including data from the present study and previous studies of hypertension was performed. Quantitative trait studies of metabolic variables were carried out in 4,387 glucose-tolerant subjects. Results: We observed minor differences in 825C>T genotype distributions for type 2 diabetes (CC/CT/TT 49/41/10% (control) vs 46/46/9% (cases), respectively, p=0.007); however, after correction for multiple testing, these were not statistically significant. No association was found with hypertension, obesity or the metabolic syndrome. Curiously, the T allele was associated with nominally lower systolic and diastolic blood pressure levels-a finding in contrast with most previous studies-but not with other metabolic variables. Meta-analysis demonstrated a high degree of heterogeneity between study populations of different ethnic origin. Although there was a tendency towards an increased risk of hypertension among 825T allele carriers, this was not statistically significant. Conclusions/interpretation: The present study suggests no major involvement of the GNB3 825C>T polymorphism in components of the metabolic syndrome.

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G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review

Semplicini

Grandi

Sandonà

et al. 2015

High Blood Press Cardiovasc Prev

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Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. The subunits of the heterotrimeric G proteins are attractive candidate gene products for susceptibility to hypertension, obesity and insulin resistance syndrome. A polymorphism (825C/T) in exon 10 of the GNB3 gene, encoding for the Gβ3 subunit, has been described. The 825T allele is associated with alternative splicing of the gene and formation of a truncated but functionally active β3 subunit. Many studies have investigated whether carriers of the 825T allele are at increased risk for hypertension, obesity, insulin-resistance and left ventricular hypertrophy with apparently conflicting results. The present review demonstrates that GNB3 825T allele is a useful genetic marker for better defining the risk profile of hypertensive patients, as it is associated with increased risk of stroke and myocardial infarction in longitudinal studies in Caucasians.

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Analysis of 825C/T Polymorphism of G Proteinβ3 Subunit in Obese/Diabetic Japanese

Cited by 17 publications

References 17 publications

Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review

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