This paper deals with the existence and uniqueness of solutions for a nonlinear boundary value problem involving a sequential ψ-Hilfer fractional integro-differential equations with nonlocal boundary conditions. The existence and uniqueness of solutions are established for the considered problem by using the Banach contraction principle, Sadovski's fixed point theorem, and Krasnoselskii-Schaefer fixed point theorem due to Burton and Kirk. In addition, the Ulam-Hyers stability of solutions is discussed. Finally, the obtained results are illustrated by examples. φ j ,ρ;ψ a +x(ς j ) = G(ξ , x(ξ )),