In this paper, we consider the well-posedness of the weakly damped stochastic nonlinear Schrödinger(NLS) equation driven by multiplicative noise. First, we show the global existence of the unique solution for the damped stochastic NLS equation in critical case. Meanwhile, the exponential integrability of the solution is proved, which implies the continuous dependence on the initial data. Then, we analyze the effect of the damped term and noise on the blow-up phenomenon. By modifying the associated energy, momentum and variance identity, we deduce a sharp blow-up condition for damped stochastic NLS equation in supercritical case. Moreover, we show that when the damped effect is large enough, the damped effect can prevent the blow-up of the solution with high probability.2010 Mathematics Subject Classification. Primary 60H35; Secondary 60H15, 60G05.