In this study, numerical simulations are conducted with the goal of exploring the impact of the direction of the moving wall, solute and thermal transport, and entropy production on doubly diffusive convection in a chamber occupied by a Casson liquid. Wall movement has a significant impact on convective flow, which, in turn, affects the rate of mass and heat transfer; this sparked our interest in conducting further analysis. The left and right (upright) walls are preserved with constant (but different) thermal and solutal distributions, while the horizontal boundaries are impermeable to mass transfer and insulated from heat transfer. Numerical solutions are acquired using the control volume technique. Outcomes under a variety of Casson fluid parameters, including Ri, Gr, buoyancy ratio, and direction of the moving wall(s), are explored, and the influences of entropy generation are comprehensively investigated. While the flow field consists of a single cell in case I, it is dual-cellular in case III for all values of the considered parameters. Comparing the three cases, the average heat and mass transport presented lower values in case III due to the movement of an isothermal (left) wall against the buoyant force, while these values are enhanced in case I. The obtained results are expected to be useful in thermal engineering, material, food, and chemical processing applications.