Analysis of Acetic Anhydride.

Calcott, W. S.; English, F. L.; Wilbur, O. C.

doi:10.1021/ie50189a026

Cited by 10 publications

(2 citation statements)

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“…The aniline method (17,25) for anhydride requires 40 minutes for the initial saponification and 60 minutes for the acetanilide reaction and is no more accurate. Modifications of that method have used benzidine (34), 2,4-dichloroaniline (2,4), m-nitroaniline (16), or anthranilic acid (12) in place of aniline, but none of these appears to improve its speed. Accurate and simple methods for determining water and acetic anhydride in glacial acetic acid have been tested in a narrow field of application to a single process.…”

Section: Discussion Of Resultsmentioning

confidence: 99%

Thermometric Determination of Water and Acetic Anhydride in Acetic Acid

Greathouse¹,

Janssen²,

Haydel³

1956

Anal. Chem.

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Section: Discussion Of Resultsmentioning

confidence: 99%

Thermometric Determination of Water and Acetic Anhydride in Acetic Acid

Greathouse¹,

Janssen²,

Haydel³

1956

Anal. Chem.

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“…example, we observed no new impurities coming from reactions with trace metal impurities (Hg, As, Pb, Cd) in nitric acid (HNO 3 ), multiple impurities from reactions with ammonia (NH 3 ), formaldehyde (HCHO), formic acid (HCOOH), carbon monoxide (CO), and carbon dioxide (CO 2 ) in hydrogen gas (H 2 ), and the lone impurity formed by reaction with acetic acid (CH 3 COOH) impurity in acetic anhydride (Ac 2 O) (Figure 3, structures in green). Known impurities in the reagents were obtained from the literature [13,14,15].…”

Section: Impurity Prediction and Propagationmentioning

confidence: 99%

AI-assisted chemical reaction impurity prediction and propagation

Mohapatra

Griffin

2022

Preprint

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Most chemical reactions result in numerous by-products and side-products, apart from the intended major product. While chemists can predict many of the main process impurities, it remains a challenge to enumerate the possible minor impurities and even more of a challenge to systematically predict and track impurities derived from raw materials or those that have propagated from one synthetic step to the next. In this study, we developed an AI-assisted approach to predict and track impurities across multi-step reactions using the main reactants, and optionally reagents, solvents and impurities in these materials, as input. We demonstrated the utility of this tool for a simple case of synthesis of paracetamol from phenol, and provide a generalized framework that covers most chemical reactions. Our solution can be applied to enable (1) faster elucidation of impurities, (2) automated interpretation of data generated from high-throughput reaction screening, and (3) more thorough raw materials risk assessments, with each of these representing key workflows in small molecule drug substance commercial process development.

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Nachweis und Bestimmung der Carboxylgruppe

Meyer

1938

Analyse Und Konstitutionsermittlung Organischer Verbindungen

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Analysis of Acetic Anhydride.

Cited by 10 publications

References 0 publications

Thermometric Determination of Water and Acetic Anhydride in Acetic Acid

Thermometric Determination of Water and Acetic Anhydride in Acetic Acid

AI-assisted chemical reaction impurity prediction and propagation

Nachweis und Bestimmung der Carboxylgruppe

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