Analysis of acute adult poisoning in a 6-year period and factors affecting the hospital stay

A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Poisoning is among the common health care problems which may be fatal and 3-5% of the acutely poisoned patients need intensive care admission. The aim of this study was to examine the acutely poisoned patients admitted to intensive care unit (ICU) in terms of individual, etiological and demographical characteristics and also to determine the factors affecting mortality. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study was retrospectively conducted on the patients admitted to medical ICU of a university hospital due to acute poisoning over a six year period. The patients' age, gender, comorbid disease status, sociocultural characteristics, cause of the poisoning, transfer time to hospital and to the ICU, signs and symptoms, laboratory data, Glasgow coma score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment score, length of stay in ICU, the treatments employed and their results were analyzed. R Re es su ul lt ts s: : The total number of the patients included in the study was 190. The median age of the patients was 28.5 (16-72) years and 97 (51%) patients were females. The mean length of stay in ICU was 4.2±3.6 days. The overall mortality rate was 8.4%. Independent risk factors for mortality were presence of concomitant physical disorders, time to ICU admission, and higher APACHE II scores. C Co on nc cl lu us si io on n: : Individual characteristics, cause of poisoning and type of toxic agent should be clearly determined since they are predictors for mortality. Early intervention is life saving. ICU scoring systems in predicting mortality are very valuable and should be used. K Ke ey y W Wo or rd ds s: : Intensive care; mortality; poisoning Ö ÖZ ZE ET T A Am ma aç ç: : Zehirlenme ölümcül olabilen ve akut zehirlenmiş hastaların %3-5'inin yoğun bakıma yatışını gerekebilen yaygın bir sağlık problemidir. Bu çalışmanın amacı mortaliteyi etkileyen faktörleri belirlemek amacıyla yoğun bakım ünitesine (YBÜ) kabul edilen akut zehirlenmiş hastaların bireysel, etyolojik ve demografik özelliklerini incelemektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çal-ışma retrospektif olarak altı yıl içinde akut zehirlenme nedeniyle bir üniversite hastanesi medikal yoğun bakımına yatan hastalar üzerinde yapıldı. Hastaların yaş, cinsiyet, eşlik eden hastalık durumu ve sosyokültürel özellikleri, zehirlenme nedeni, hastane ve yoğun bakıma transfer süresi, belirti ve bulguları, laboratuvar verileri, Glasgow koma skoru, Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi II (APACHE II) skoru, Ardışık Organ Yetersizliğinin Değerlendirilmesi skoru, YBÜ yatış süresi, tedavileri ve sonuçları analiz edildi. B Bu ul lg gu ul la ar r: : Çalışmaya dahil edilen hastaların toplam sayısı 190 idi. Hastaların ortanca yaşı 28,5 (16-72) yıldı ve 97 (%51) hasta kadın idi. Yoğun bakımda kalış süresi ortalama 4,2±3,6 gün idi. Mortalite oranı % 8,4 idi. Mortalite için bağımsız risk faktörleri fiziksel alt hastalığı...

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“…9 Another study by Satar et al confirmed the same gender distribution data. 13 Our age groups are similar to these studies.…”

Section: Discussionsupporting

confidence: 90%

Predictors of Mortality in Critically Ill Patients with Poisoning: A Single Center Experience

Coşkun¹,

Gündoğan²,

Atağ³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…[4] Suicide attempts using calcium channel antagonists shows a significantly higher mortality. [5,6] Increasing elder population in Turkey, increased the number of patients using cardiovascular drugs. Hence, the need exists for studies regarding the incidence and features of cardiovascular drug toxicity.…”

Section: Introductionmentioning

confidence: 99%

Suicidal Cardiovascular Drug Intoxication in Emergency Department

Ayhan¹,

Özüçelik²,

Doğan³

et al. 2015

HSP

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Hastaların çoğu destek tedavisi ile taburcu olmuştur. Hastaların hastanede kalış süresi ortalama 16,6 ± 10.6 saattir (2-48 saat). Bir hasta beta bloker kullanımına bağlı kardiyojenik şok sonucu ölmüştür. Sonuç: Bu araştırma ACE inhibitörleri ile intoksikasyonlarda bir artış olduğunu göstermiştir. Son zamanlarda kardiyovasküler ilaçların kolay bulunması nedeniyle, özellikle genç intoksikasyon hastalarında aile de ilaç kullanım öyküsü daha detaylı sorgulanmalıdır. Kardiyovasküler ilaçların satışındaki kontrolün ve kısıtlamanın arttırılması bu ilaçlarla olan suicidal girişimleri azaltabilir. Anahtar kelimeler: Kardiovasküler ilaçlar, zehirlenme, ilaçlı intihar, epidemiyolojiAbstract Objectives: As elderly population in Turkey increases, patients using cardiovascular drugs increases.Access to these drugs for suicide attempt gets easier due to common use. Aim of the study is to evaluate the results of intoxication with cardiovascular drugs. Methods: Data of 1399 patients admitted to two level 1 hospital emergency departments for drug intoxication were reviewed from July 2009 to March 2014 retrospectively. Cardiovascular drug intoxication was diagnosed in 81 patients. Results: The average age of 1318 patients with other drug intoxication was 25.9± 10.8 years (72,9% female, 27,1% male); the average age of 81 patients (72,8% female, 27,2% male) with cardiovascular drug toxicity was 27,3± 13,6 years. Ten different group cardiovascular drugs were taken. The most common cardiovascular drug (39.5%) was found ACEI group. Beta blocker intoxication was 37%. Most of the patients required supportive treatment. Average length of stay was 16,6±10,6 h (range: 2-48 h). One patient died from cardiogenic shock due to beta blocker toxicity. Conclusion: Our study shows an increase in suicidal ACE inhibitor and beta blocker intoxication in cardiovascular drugs. All drug intoxications are more common between 18:00 and 02:00 o'clock. Seasonal distribution of suicide attempts showed a peak incidence in fall. Especially in young intoxication patients, physicians should take detailed information about the use of cardiovascular drugs by family members to rule out possible cardiovascular drug intoxication.

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“…Metal phosphide compounds are widely used as rodenticides and insecticides in Turkey (2). AP is manufactured in the solid form and is stored as packed huge tablets and granules.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Aluminum Phosphide Poisoning with Continuous Veno-venous Hemofiltration: A Case Report

Açıkalın¹,

Dişel²,

Karakoç³

et al. 2016

J Emerg Med Case Rep

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Herein we aim to discuss the case of a patient with AP poisoning in a suicide attempt and who was successfully treated with continuous veno-venous hemofiltration. Case ReportA-24-year old lady was admitted to an urban hospital with complaints of dizziness, numbness in the face, and nausea and vomiting after taking two tablets of AP. Gastric lavage was performed, and she was given n-acetylcysteine, magnesium sulfate,

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Analysis of acute adult poisoning in a 6-year period and factors affecting the hospital stay

Cited by 46 publications

References 19 publications

Predictors of Mortality in Critically Ill Patients with Poisoning: A Single Center Experience

Predictors of Mortality in Critically Ill Patients with Poisoning: A Single Center Experience

Suicidal Cardiovascular Drug Intoxication in Emergency Department

Successful Treatment of Aluminum Phosphide Poisoning with Continuous Veno-venous Hemofiltration: A Case Report

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