Analysis of Adverse Drug Reactions of Atypical Antipsychotic Drugs in Psychiatry OPD

Abstract

Background:Novel atypical antipsychotics are superior to conventional antipsychotics as they significantly reduce both positive and negative symptoms of schizophrenia and have lower risk of extrapyramidal symptoms (EPS). However, these drugs have separate set of adverse drug reactions (ADRs). Therefore, this study was carried out to assess these ADRs, which can have impact on long-term compliance and achieving successful treatment.Materials and Methods:A prospective study of analysis of ADR of atypical antipsychotic drugs was carried out in the psychiatry outpatient department. Patients of psychotic disorder (any age, either sex), who were prescribed atypical antipsychotic drugs, were included. Those who were prescribed conventional antipsychotics or combinations of antipsychotics were excluded from the study. Apart from spontaneously reported ADRs, a questionnaire related to the likely ADR was used and patients’ responses were recorded in the case record form.Results:Totally 93 ADRs were recorded from 84 prescriptions. Majority of the ADRs (82 out of 93) were seen with risperidone and olanzepine, as they were the commonly prescribed drugs. Weight gain, dizziness, sleep disturbance and appetite disturbance accounted for nearly 78% of the total events. With risperidone (at 4–6 mg/day) and olanzepine (at 10–15 mg/day), gastrointestinal and sleep disturbance were observed in the initial (within 7 days to 2–3 months after treatment) course of treatment, while EPS, fatigue, seizure, increased frequency of micturition and dizziness were observed after long-term (3–9 months) use.Conclusion:The present study adds to the existing information on the prevalence of adverse effects of atypical antipsychotic drugs. Role of active surveillance in post-marketing phase is also emphasized.

Pharmacovigilance study in psychiatry out-patient department of a tertiary care teaching hospital

“…1 Most common ADRs produced by olanzapine in the present study was weight gain, increased appetite and diabetes mellitus, similar to study conducted by Shah et al, Sengupta et al and Kiran et al 1,3,12 Haloperidol produced maximum extrapyramidal symptoms similar to study conducted by Taruna et al 4 Extrapyramidal symptoms can impair quality of life, stigmatise patients and lead to poor antipsychotic adherence and relapse.…”

An evaluation of adverse drug reactions monitoring at a pharmacovigilance unit under pharmacovigilance program of India in a tertiary care hospital of Haryana

“…The demographic details of the present analysis showed male gender predominance over females w.r.t ADRs, which was similar to the findings of some other studies. 16,17 Several other studies have found that ADRs are more common in females than in males. 18,19 However, another study showed no difference in the occurrence of ADRs in male and female patients 20 showing thereby that the influence of gender may be incidental only and have no influence on the number of ADRs reported.…”

Adverse drug reactions in a tertiary care teaching hospital in India: analysis of spontaneously reported cases

“…Olanzapine most commonly involved in weight gain while risperidone caused extrapyramidal symptoms that are in line with the previous study. 29 One Indian study observed olanzapine and haloperidol as most common offending drugs among psychiatric outpatients. 30 The difference for common antipsychotics may be due to the difference in utilization pattern of drugs.…”