Analysis of aluminum, minerals and trace elements in the milk samples from lactating mothers in Hamadan, Iran

Javad, Masoumeh Taravati; Vahidinia, Aliasghar; Samiee, Fateme; Elaridi, Jomana; Leili, Mostafa; Faradmal, Javad; Rahmani, Alireza

doi:10.1016/j.jtemb.2018.05.016

Cited by 30 publications

(19 citation statements)

References 60 publications

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“…Aluminum is the most abundant metal in the earth's crust (soil, water, and air), as well as the most frequent and highly concentrated element in breast milk ( ATSDR, 2008 ; Bastos et al, 2018 ). However, Al concentration in our HM-baseline and HM-concentrate was lower than that reported by studies conducted in Iran ( Taravati Javad et al, 2018 ) and Spain ( Martínez et al, 2019 ) ( Table A2 ). It is important to note that only a small amount of Al enters the infant's body through breastfeeding ( ATSDR, 2008 ).…”

Section: Resultscontrasting

confidence: 81%

“…Previous studies conducted in Greece ( Leotsinidis et al, 2005 ), Sweden ( Björklund et al, 2012 ), Chile ( Castro et al, 2014 ), Australia ( Mohd-Taufek et al, 2016 ), Switzerland ( Sabatier et al, 2019 ), and Brazil ( Alves Peixoto et al, 2019 ) detected lower Fe content in breast milk compared to the values found in the present study ( Table A1 ). Furthermore, Fe content in HM samples collected 1–2 months postpartum was higher than in samples collected after 6–7 months and 12 months of lactation ( Taravati Javad et al, 2018 ). Therefore, despite the higher baseline Fe content of the HM-baseline used in the present study, the concentration process maintained the high Fe content ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low birth weight admitted to neonatal intensive care units. However, further details need to be elucidated about HM-concentrate composition, particularly its content of essential and potentially toxic trace elements. Therefore, this study aimed to determine the concentration of essential and toxic elements in human milk considered baseline (HM-baseline) and HM-concentrate, as well as to quantify changes in concentration of these elements after the HM concentration process. The concentration of Aluminum, Arsenic, Cadmium, Chromium, Iron, Mercury, Manganese, Nickel, Lead, Selenium, Tin, and Thallium was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Moreover, Bayesian linear mixed effect models were applied to estimate the mean difference between HM-baseline and HM-concentrate samples. After comparison (HM-concentrate versus HM-baseline), a significant increase in concentration was observed only for Manganese (0.80 μg/L; 95% CrI [0.16; 1.43]) and Selenium (6.74 μg/L; 95% CrI [4.66; 8.86]), while Lead concentration (−6.13 μg/L; 95% CrI [-8.63; −3.61]) decreased. This study provides latest and reliable information about HM composition. After milk concentration by lyophilization, there was a significant increase only in the essential elements Manganese and Selenium. The essential micronutrient content in HM-concentrate was similar or higher than that in preterm mothers' milk, which suggests it is viable for nutritional support of preterm infants. In addition, the low concentrations of potentially toxic elements in HM-concentrate indicates that it is safe for consumption by premature newborns.

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Section: Resultscontrasting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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“…It is also speculated that zinc is the first limiting nutrient in breast milk, because the decline in zinc amount from colostrum to mature milk is substantial: from about 4 mg per day during the first days postpartum to approximately 0.7 mg per day by six months [ 7 , 8 , 9 ]. Some studies [ 10 , 11 , 12 ] indicate that zinc intake from breast milk for babies under six months of age can already be lower than recommended. Nevertheless, the time period during which breast milk alone can provide the necessary zinc amount remains uncertain [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc Content in Breast Milk and Its Association with Maternal Diet

et al. 2018

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Background: Zinc is an indispensable element, being involved in many biological processes. Correspondingly, insufficient zinc intake in early youth can detrimentally affect the function of a growing body. The aim of this study was to determine zinc content in breast milk among lactating women in Latvia and factors (maternal diet; mother’s and baby’s characteristics; breastfeeding pattern) affecting it. Methods: In total, 62 mature milk (at least one month postpartum) samples were collected and pooled within 24 h. Zinc content (mg 100 mL−1) was determined using inductively coupled plasma mass spectrometry (ICP-MS; Agilent 7700×, Agilent Technologies, Tokyo, Japan). Results: Zinc content in mature breast milk ranged from 0.01 to 0.34 mg 100 mL−1 with a median (interquartile range) content of 0.10 (0.05–0.15) mg 100 mL−1. Time postpartum was a significant negative predictor for zinc content in breast milk (r = −0.500; p = 0.000). Median maternal zinc intake was 10.70 (7.24–15.27) mg. Yet, zinc content in breast milk was unaffected by maternal dietary zinc intake (r = 0.155; p = 0.221). Conclusions: Maternal dietary zinc intake was nearly the recommended intake for lactating women (11 mg), but due to low zinc content in breast milk, babies in Latvia might not receive sufficient zinc intake. Future research should aim for the assessment of zinc status by evaluating plasma or serum levels of both mothers and babies.

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“…Trace element deficiencies frequently contribute to poor growth, intellectual impairments, and perinatal complications, 4 whereas an excess of these elements can be detrimental 5 . It is widely known that breast milk concentrations of several trace elements such as iron (Fe), zinc (Zn), and copper (Cu) are not affected by either the mothers’ diet or nutritional status, and that clinically apparent deficiencies and excesses of these elements are rare in breastfed infants at least for the first 6 months of life 6–9 . The breast milk concentrations of these elements have been reported to be accurately regulated by complicated mechanisms in the mammary epithelial cells 6,9 .…”

mentioning

confidence: 99%

Trace element levels in mature breast milk of recently lactating Japanese women

Motoyama

Isojima

Sato

et al. 2021

Pediatrics International

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Background Many trace elements are essential for infant growth and development during early life. Their concentrations in breast milk vary depending on social and economic factors. Nonetheless, the present available values in Japan were derived from lactating mothers approximately 15 years ago. Methods Healthy mothers who gave birth to a single infant after 37 weeks of gestation at Teikyo University Hospital were recruited between July 2016 and December 2017. They were encouraged to collect breast milk samples and a self‐administered food frequency questionnaire at 1 and 3 months postpartum. Anthropometric data for the mothers and their infants were also collected. Overall, 79 subjects were analyzed after excluding subjects with inadequate data in the food frequency questionnaire, insufficient breast milk samples, and medication that could affect dietary intakes. Trace element concentrations were determined by inductively coupled plasma mass spectrometry, and their correlation with several factors were investigated. Results Trace element concentrations were widely distributed as previously reported. Median concentrations of Cr, Mn, Fe, Cu, Zn, Se, and Mo were 0.8, 0.8, 98, 50, 272, 2.2, and 0.7 µg/dL at 1 month postpartum and 0.6, 0.7, 55, 33, 177, 2.1, and 0.7 µg/dL at 3 months postpartum, respectively. There were no correlations between trace element concentrations and either mothers’ intakes or infants’ growth. In contrast, there were significant correlations between several trace elements and macronutrients in addition to inter‐element correlations among almost all trace elements. Conclusions Trace element concentrations in mature breast milk were determined from recently lactating mothers in Japan.

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Analysis of aluminum, minerals and trace elements in the milk samples from lactating mothers in Hamadan, Iran

Cited by 30 publications

References 60 publications

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Zinc Content in Breast Milk and Its Association with Maternal Diet

Trace element levels in mature breast milk of recently lactating Japanese women

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