Analysis of Aminotransferases in Predialysis Chronic Kidney Disease Patients

Shittu, Mujeeb Olushola; Adelakun, Ayodele Ademola; Eegunjobi, Anifat; Idowu, Olufemi; Shittu, Bashirat Tolulope

doi:10.9790/0853-13468789

Cited by 3 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are consistent with previous studies conducted by Alhawish et al and Sette and Lope. 13,14 Our study also demonstrated that the mean serum AST and ALT levels were significantly lowered when the severity and clinical stages of CKD is increased, which isin line with several prior reports [ 12 , 14 , 15 , 26 , 27 ]. The strong positive correlations between the serum levels of AST and ALT with eGFR in the current study indicate that as the severity of CKD increases, the mean values of aminotransferases significantly decreased.…”

Section: Discussionsupporting

confidence: 89%

“…However, there are some suggested mechanisms by which aminotransferases are reduced as the severity of the CKD is increased. The most common proposed causes are vitamin B 6 deficiency [ 29 ], an accumulation of lactate and uremic toxins [ [30] , [31] , [32] ], induction of hepatocyte growth factors (HGFs), stimulation of interferon-α [ 27 , 33 ], hemodilution caused by water retention, and accelerated clearance of aminotransferase in CKD patients undergoing dialysis [ 15 , 31 , 34 ].Hence, further large-scale studies are required to understand the mechanism of the lowering of liver enzymes in CKD patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of liver function biomarkers, blood pressure, and anthropometric parameters among chronic kidney disease patients: Laboratory-based cross-sectional study in Northwest Ethiopia

Agidew,

Abebe,

Muche

et al. 2023

Metabolism Open

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Evaluation of liver function biomarkers, blood pressure, and anthropometric parameters among chronic kidney disease patients: Laboratory-based cross-sectional study in Northwest Ethiopia

Agidew,

Abebe,

Muche

et al. 2023

Metabolism Open

View full text Add to dashboard Cite

“…Our study reported mean ALT (19.0 -54.0) in hemodialysis group and for non-hemodialysis CKD group it was (21.0 -45.0) with (P=0.326) which is not significant, and for AST it was (22.0 -48.0) in hemodialysis patients and in nonhemodialysis CKD group patents it was (16.0 -42.0) with significant value (p<0.001). This result may be due to that IBS has an impending adverse effect on serum liver enzymes AST and its components possibly due to its effect on nutrient absorption, food digestion, or dietary pattern (Gadour, et al, 2021) [12] against to our study (Shittu, M. et al, 2014) [33] , it reported mean ALT (7.1± [30] Hypertension was significantly higher in patients with IBS than those without, HTN in IBS patients was 34 (57.6%) but in those without IBS were 14 (34.1%).…”

Section: Resultscontrasting

confidence: 55%

Irritable bowel syndrome frequency and related factors in hemodialysis patients

Kadh,

Enaba,

Okda

et al. 2023

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

Background: The incidence of gastrointestinal system (GIS) issues in patients with chronic kidney disease (CKD) is quite high. IBS, one of the GIS disorders, is more prevalent among patients undergoing dialysis. Patients with IBS are more susceptible to psychiatric disorders such as depression and anxiety (CKD). The purpose of the work: is determining the prevalence of IBS and its associated factors among CKD patients undergoing hemodialysis. Method and materials: A cross-sectional research was conducted on a group of 200 patients who were receiving hemodialysis. The patients were categorized into two distinct groups: Group A: 100 patients of CKD on hemodialysis and Group B: 100 patients of CKD on non-hemodialysis treatment. All Patients diagnosed to have IBS in hemodialysis according to ROME IV criteria. The presence of depression and anxiety was assessed using the Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). Results: In our study IBS in hemodialysis group was significantly (59%) in comparison to nonhemodialysis CKD group was (44%). In this current study we had found depressive symptoms in a significant percentage of patients more than (64%) among those in dialysis and (47%) among those in non-hemodialysis CKD group. In our study, we had found anxiety symptoms in a significant percentage of patients more than (62%) among those in dialysis and (41%) among those in nonhemodialysis CKD group. Patients with IBS had substantially higher ratings for anxiety and sadness compared to those without IBS (p<0.029 and p<0.001, respectively). Conclusion: Patients undergoing hemodialysis were more likely to have IBS, according to our research. A greater prevalence of depression and anxiety was observed as well in the hemodialysis group when contrasted with the non-hemodialysis CKD group.

show abstract

“…Two studies with large sample sizes have suggested that the cutoff value should be defined by considering both gender and the body mass index (15,18). In accordance with the previous reports that have highlighted the importance of gender in the transaminases concentration (19), in this study also we considered this factor; in total, 639 males and 477 females were investigated.…”

Section: Discussionmentioning

confidence: 74%

“…According to the findings of Mujeeb et al (2014) and Noha et al (2016) (19,20), that investigated both males and females, transaminase levels were significantly lower when comparing each dialysis (CAPD-HD) group with the control group (P < 0.0001). As found by the present study, the AST level was significantly higher in the control group than the dialysis groups (P = 0.0001).…”

Section: Discussionmentioning

confidence: 89%

Evaluation of Liver Enzymes in End-Stage Renal Disease Patients on the Renal Transplant-Waiting List in North-West of Iran

et al. 2020

View full text Add to dashboard Cite

Background: Liver diseases, mainly hepatitis B and C, commonly occur in patients with end-stage renal diseases (ESRD). Alanine and aspartate aminotransferase are important for the diagnosis and monitoring of liver diseases. Several studies demonstrated that patients with chronic kidney disease (CKD) have lower levels of serum aminotransferases than the normal population. The present study was designed to compare these enzymes in different types of dialysis in ESRD patients and the general population in Iran. Methods: In this cross-sectional study, ESRD patients who were candidates for organ transplants in Montaserieh Hospital in Mashhad (Iran) from 2007 to 2014 were enrolled. The data of 1116 patients were collected by reviewing their medical records. Patients were divided into two groups of hemodialysis (n = 1034) and peritoneal dialysis (n = 82); their liver enzymes were compared with 510 healthy individuals from the MASHAD study. Results: There was a significant difference between hemodialysis and peritoneal dialysis patients and the control group regarding the age (P < 0.0001) and gender (P = 0.005). Conclusions: The reduction in serum aminotransferase levels in ESRD cases compared to the control group suggested that renal failure influences liver enzymes that were mildly increased in peritoneal dialysis versus hemodialysis patients in samples provided before the dialysis session.

show abstract

Analysis of Aminotransferases in Predialysis Chronic Kidney Disease Patients

Cited by 3 publications

References 15 publications

Evaluation of liver function biomarkers, blood pressure, and anthropometric parameters among chronic kidney disease patients: Laboratory-based cross-sectional study in Northwest Ethiopia

Evaluation of liver function biomarkers, blood pressure, and anthropometric parameters among chronic kidney disease patients: Laboratory-based cross-sectional study in Northwest Ethiopia

Irritable bowel syndrome frequency and related factors in hemodialysis patients

Evaluation of Liver Enzymes in End-Stage Renal Disease Patients on the Renal Transplant-Waiting List in North-West of Iran

Contact Info

Product

Resources

About