Analysis of an Indian diabetes prevention programme on association of adipokines and a hepatokine with incident diabetes

Abstract

To study the association and possible predictive role of visfatin, resistin, fetuin-A and chemerin with incident type 2 diabetes (T2DM) among Asian Indians with prediabetes. Their association with insulin resistance, β-cell function, glycaemia and anthropometry were also studied. This is a nested case–control study of a large 2-year prospective prevention trial in persons at high risk of developing T2DM. Baseline HbA1c values between 6.0% (42 mmol/mol) and 6.2% (44 mmol/mol) were chosen for this analysis (n = 144). At follow-up, persons with incident T2DM (HbA1c ≥ 6.5%, 48 mmol/mol) were grouped as cases (n = 72) and those reverted to normoglycaemia, (HbA1c < 5.7% (39 mmol/mol) as controls (n = 72). Insulin resistance showed the strongest association with incident T2DM ((Odds Ratio (OR): 23.22 [95%CI 6.36–84.77]; p < 0.0001). Baseline visfatin (OR: 6.56 [95%CI 2.21–19.5]; p < 0.001) and fetuin-A (OR: 1.01 [95%CI (1.01–1.04)]; p < 0.0001) independently contributed to the conversion of prediabetes to T2DM. The contribution was significantly higher when their elevated levels coexisted (OR: 12.63 [95%CI 3.57–44.63]; p < 0.0001). The area under the curve was 0.77 ± SE 0.4 (95%CI 0.69–0.85) and 0.80 ± SE 0.04 (95%CI 0.73–0.88) for visfatin (median 17.7 ng/ml, sensitivity and specificity: 75%, p < 0.0001) and fetuin-A (mean 236.2 µg/ml, sensitivity: 71%, specificity: 75%, p < 0.0001) respectively. Higher baseline visfatin and fetuin-A concentrations are strongly associated with incident T2DM and are predictive of future diabetes.

Magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus

“…In a prior study, Ruan et al [ 11 ] showed that endolipin is an independent risk factor for the occurrence of stroke in hypertensive patients. Susairaj et al [ 12 ] showed that serum endostatin predicted type 2 diabetes mellitus with an AUC of 0.77 and a sensitivity and specificity of 75%. Kumar et al [ 13 ] stated that Gal-3 expression is closely related to the risk of microvascular complications in patients with type 2 diabetes mellitus, and could be used as a valid factor in the diagnosis and evaluation of microvascular and macrovascular complications in patients with type 2 diabetes mellitus.…”

Underestimated Prediabetic Biomarkers: Are We Blind to Their Strategy?

“…Fetuin-A was also associated with diabetic risk factors. Baseline levels of Fetuin-A independently contributed to the progression of prediabetes to T2D (54). Fetuin-A is capable of crossing the blood-brain barrier and is associated with depression regardless of insulin sensitivity status (55).…”