Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy

Zheng, Ce; Guzman, Celeste; Cheung, Carol Y.; He, Yingke; Friedman, David S.; Ong, Sim Heng; Narayanaswamy, Arun; Chew, Paul; Perera, Shamira A.; Aung, Tin

doi:10.1001/jamaophthalmol.2013.567

Cited by 21 publications

(16 citation statements)

References 36 publications

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“…[7][8][9][10][11][12][13]33,52,54,55 We have demonstrated that eAS-OCT is capable of evaluating the angle configuration and providing quantitative assessments of all these parameters using one device. Recent studies indicate that several important factors may be associated with the angle closure, such as ACD, LVa, LT, iris thickness, iris curvature, and iris dynamics.…”

Section: Discussionmentioning

confidence: 96%

“…The most successful application of OCT has been in ophthalmology, where the technology has become an indispensable tool to image both the anterior segment (e.g., cornea and anterior chamber angle) and the posterior segment (e.g., retina) of the human eye. Clinical uses include evaluating iridocorneal angle and identifying risk factors in primary angle closure glaucoma (PACG), [3][4][5][6][7][8][9][10][11][12][13] visualizing cornea, anterior chamber, and crystalline lens in refractive surgery, such as in laser in situ keratomileusis (LASIK) and phakic or pseudophakic intraocular lens (IOL) implantation, [14][15][16][17][18][19][20] assessing the dynamic response of AS during physiological accommodation and assessing ametropia, particularly for eyes undergoing IOL surgery. Izatt et al were the first to report the use of OCT to noninvasively visualize the cornea and anterior chamber in 1994.…”

Section: Introductionmentioning

confidence: 99%

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Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Johnstone

Wang

2014

J. Biomed. Opt.

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We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μm, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument's utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens vault, crystalline lens thickness, angle opening distance (AOD500/AOD750), and the area described by the trabecular-iris space (TISA500/TISA750) at 500/750 μm. We also use eAS-OCT to image and quantify dynamic functional changes of the AS in response to a light stimulus that induces physiological pupillary changes as well as accommodative efforts that induce lens changes. The results show that the described eAS-OCT is able to provide full anatomical biometry for AS and is useful for the studies where the dynamic response of AS compartment to certain stimulus is required.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

Johnstone

Wang

2014

J. Biomed. Opt.

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“…Anterior chamber width (ACW) was defined as the length between the scleral spurs on the two opposite sides (Zheng et al. ). Pupil diameter (PD) was measured as the distance from one side to the opposite side of the pupillary tip of the iris on the images by ASOCT.…”

Section: Methodsmentioning

confidence: 99%

“…Anterior chamber depth (ACD) was defined as the length of the central perpendicular line between the anterior surface of the lens and the posterior surface of the cornea. Anterior chamber width (ACW) was defined as the length between the scleral spurs on the two opposite sides (Zheng et al 2013). Pupil diameter (PD) was measured as the distance from one side to the opposite side of the pupillary tip of the iris on the images by ASOCT.…”

Section: Image Processingmentioning

confidence: 99%

Influence of exercise on the structure of the anterior chamber of the eye

Song

Zhao

Yan

et al. 2017

Acta Ophthalmologica

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PurposeTo measure changes in anterior chamber structure before and after exercise in healthy individuals using anterior segment optical coherence tomography (ASOCT).MethodsThirty‐two healthy young individuals performed jogging for 20 min. Eye blinking rate was recorded during rest and exercise. The anterior chamber angle (ACA), angle opening distance at 500 μm from the scleral spur (AOD500), trabecular‐iris space area at 500 μm from the scleral spur (TISA500), iris concavity (IC), iris concavity ratio (CR), iris thickness at 750 μm from the scleral spur (IT750), anterior chamber depth (ACD), anterior chamber width (ACW), pupil diameter (PD), intraocular pressure (IOP), blood pressure (BP) and heart rate (HR) were recorded before and after exercise. Anterior chamber angle (ACA), AOD500, TISA500, IC, IT750, ACD, ACW and PD were measured with ASOCT.ResultsCompared with rest, the blinking rate during exercise did not change significantly (13.04 ± 5.80 versus 13.52 ± 5.87 blinks/min, p = 0.645). The average IOP (15.4 ± 2.4 versus 12.4 ± 2.1 mmHg), ACA (35.96 ± 11.35 versus 40.25 ± 12.64 degrees), AOD500 (0.800 ± 0.348 versus 0.942 ± 0.387 mm), TISA500 (0.308 ± 0.155 versus 0.374 ± 0.193 mm2), IC (−0.078 ± 0.148 versus −0.153 ± 0.159 mm) and CR (−0.027 ± 0.050 versus −0.054 ± 0.056) changed significantly (all p < 0.001), while the average IT750 (0.463 ± 0.084 versus 0.465 ± 0.086 mm; p = 0.492), ACD (3.171 ± 0.229 versus 3.175 ± 0.238 mm; p = 0.543) and ACW (11.768 ± 0.377 versus 11.755 ± 0.378 mm; p = 0.122) showed no significant change after exercise.ConclusionThe blinking rate did not change significantly during exercise, while ACA, AOD500 and TISA500 increased after exercise. Exercise also induced or increased IC. These changes in anterior chamber structure were only associated with exercise, but not with the postexercise change in PD or IOP.

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“…The accuracy of this device is based on camera resolution and measurement distance, which avoid accommodation (Silbert et al 2013). The advantage of using an infrared automated pupillometer is that the pupil size does not change while measurements are taken, minimizing the effect of hippus (Zheng et al 2013).…”

Section: Referencesmentioning

confidence: 99%