Analysis of antibiotic susceptibility patterns of Helicobacter pylori isolates from Malaysia

Ahmad, Norazah; Zakaria, Wan Rasinah; Rosmawati, Mohamed

doi:10.1111/j.1523-5378.2010.00816.x

Cited by 36 publications

(44 citation statements)

References 34 publications

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“…However, we observed no resistance to TCN, consistent with reports from other countries [35][36][37][38], but in contrast to studies from India and Pakistan [39][40][41]. This difference may in part be attributed to different usage of this antibiotic in various countries.…”

Section: Discussioncontrasting

confidence: 52%

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Aftab

Miftahussurur

Subsomwong

et al. 2016

J Infect Dev Ctries

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Introduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin in Bangladesh. Methodology: This study included 133 consecutive patients who underwent endoscopy examination at Dhaka Medical College in November 2014. The serial two-fold agar dilution method was used to determine the minimum inhibitory concentrations of the five antibiotics. Results: Among 56 cultured strains, H. pylori showed high rates of resistance to clarithromycin and metronidazole (39.3% and 94.6%, respectively). Moreover, levofloxacin showed an emerging antimicrobial resistance pattern (66.1%), which was higher in patients with gastritis than that in those with peptic ulcers (p = 0.02). The resistance rate of levofloxacin was significantly higher in patients living in Dhaka city compared to those living in the village (p = 0.049). However, amoxicillin and tetracycline resistance rates were very low. Resistance to both metronidazole and levofloxacin was most commonly observed. Conclusions: The rates of resistance to clarithromycin, metronidazole, and levofloxacin were high in Bangladesh, which suggests that triple therapy based on these drugs may not be useful as first-line therapies in Bangladesh. Alternative strategies such as furazolidone-based triple therapy, bismuth-based quadruple therapies, or sequential therapy may be more effective for patients in in Bangladesh.

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Section: Discussioncontrasting

confidence: 52%

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Aftab

Miftahussurur

Subsomwong

et al. 2016

J Infect Dev Ctries

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“…The MIC was identified by the point of intersection of the inhibition zone with the E-test strip, as previously described. [5][6][7][8] Strains were considered resistant when the MIC value was > 0.12 μg/mL for AMX, > 0.5 μg/mL for CLR, > 1 μg/mL for LVX, > 1 μg/mL for CIP, > 8 μg/mL for MNZ, and > 1 μg/mL for TET. The breakpoints are based on epidemiological cutoff values, which distinguish wild-type isolates from those with reduced susceptibility by using the European Committee on Antimicrobial Susceptibility Testing criteria (2012).…”

Section: Methodsmentioning

confidence: 99%

Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand

Vilaichone¹,

Ratanachu‐ek²,

Gamnarai³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. This study aimed to survey the prevalence, patterns of antibiotic resistance, and clinical factors associated with antibiotic resistance in Helicobacter pylori among the Karen and Hmong mountain people of Thailand. We recruited dyspeptic patients in the Maesod district, Tak Province, Thailand. All subjects underwent upper gastrointestinal endoscopy, and three antral gastric biopsies were obtained for rapid urease tests and culture. An epsilometer was used to determine the minimum inhibitory concentrations of amoxicillin (AMX), clarithromycin (CLR), metronidazole (MNZ), levofloxacin (LVX), ciprofloxacin (CIP), and tetracycline (TET). A total of 291 subjects were enrolled; 149 (51.2%) were infected with H. pylori. Helicobacter pylori infection was present in 47.1% of Thai, 51.7% of Karen, and 58.7% of Hmong subjects. Antibiotic resistance was present in 75.8% including AMX (0.8%), TET (0%), CLR (5.6%), MNZ (71.8%), CIP (19.4%), LVX (19.4%), and multidrug resistance in 21.8%. Karen subjects had the highest prevalence of MNZ resistance (84.6%), and Hmong subjects had the highest prevalence of fluoroquinolone (27.3%) and multidrug (34.1%) resistance. MNZ plus fluoroquinolone (14.5%) was the most common multidrug resistance. There was no association between clinical factors and antibiotic resistance. MNZ resistance was prevalent, whereas fluoroquinolone-and multidrug-resistant H. pylori infections are important problems in mountain people of Thailand.

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“…Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin are among the antibiotics utilized for the eradication of H. pylori infections (2,3). However, resistance to antibiotics is a major problem in effective treatment (2). Clarithromycin is the most effective antimicrobial used for the treatment of H. pylori infection, and resistance to this drug is the major cause of treatment failure (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…These diseases may regress or be completely cured after therapy with antibiotics to eradicate H. pylori. Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin are among the antibiotics utilized for the eradication of H. pylori infections (2,3). However, resistance to antibiotics is a major problem in effective treatment (2).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of A2143G and A2144G Point Mutations Responsible for Clarithromycin Resistance among Helicobacter pylori Strains in Bushehr, Iran

Tajbakhsh

Falahi²,

Motamed³

et al. 2016

Avicenna J Clin Microbiol Infect

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Background: Resistance to clarithromycin in Helicobacter pylori has become one of the most important reasons for failure of antibiotic eradication therapies. This resistance is predominantly caused by point mutations in the peptidyl transferase region of 23S rRNA. Objectives: The aim of this study was to determine the prevalence of the A2143G, A2144G, and A2143C point mutations among H. pylori strains from gastric biopsy specimens in Bushehr, in the southwest of Iran. Patients and Methods: Gastric biopsy specimens were obtained from patients with upper gastrointestinal symptoms during endoscopy. Fluorescent in situ hybridization (FISH) using oligonucleotide probes was applied to detect the point mutations responsible for clarithromycin resistance in H. pylori. Results: Of the 135 H. pylori-positive specimens, two harbored strains with the A2143G mutation and nine contained strains with the A2144G mutation. Thus, the prevalences of the A2143G and A2144G point mutations were 1.5% and 6.7%, respectively. The A2143C point mutation was not found. Conclusions:The prevalences of the point mutations A2143G and A2144G were low in our geographic area. Based on the findings of this study, clarithromycin still seems to be a useful antibiotic for initial treatment regimens in Bushehr, Iran.

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Analysis of antibiotic susceptibility patterns of Helicobacter pylori isolates from Malaysia

Cited by 36 publications

References 34 publications

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand

Prevalence of A2143G and A2144G Point Mutations Responsible for Clarithromycin Resistance among Helicobacter pylori Strains in Bushehr, Iran

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