Analysis of antibiotic treatment of children in a Shanghai tertiary hospital based on point prevalence surveys

Xu, Jiachen; Gao, Jie; Guo, Junhua; Song, Lili

doi:10.1186/s12879-020-05542-1

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…We could only make a preliminary estimate based on experience. The top three antibiotics administered in children patients were cephalosporins (43.8%), penicillins (13.2%), and carbapenems (8.7%) [10], which led to changes of gut microbiota in the study. Detailed pre-admission antibiotic use records are still in progress.…”

Section: Discussionmentioning

confidence: 99%

Effect of Antibiotics on The Gut Microbiota in Children with Chronic Pancreatitis

Wang¹,

Yuan²,

Ma³

et al. 2021

JJGH

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Objectives: Little is known about the effect of antibiotic treatment on the gut microbiota in children with chronic pancreatitis (CCP). Our objective was to identify the effect of antibiotic treatment on the gut microbiota in children with chronic pancreatitis (CCP), the main gut microbiota genera and characterize the patients’ functional mutations after using antibiotics. Methods: The 16S rRNA sequencing method was used to compare the gut microbiota of healthy controls (HCs) with CCP using and not using antibiotics. Results: All CCP demonstrated a significantly reduced alpha diversity of the gut microbiota (P＜0.01). The gut microbiota's alpha diversity and the abundance of genera’s beta diversity did not show statistical differences between the non-antibiotics and antibiotics groups. There were 15 altered genera with common abundance in the non-antibiotics and antibiotics groups compared to the HC group. The area under the curve (AUC) of the top three probiotics, i.e., Faecalibacterium, Eubacterium, and Subdoligranulum, was 0.91. Among the 13 genera altered in the non-antibiotics group, the top three genera were not appropriate as biomarkers for cases receiving antibiotics. Compared to these 13 genera, the differences between the genera and the proportion of gram-positive bacteria in the 17 genera altered only in the antibiotics group were not statistically significant. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that the antibiotics caused alterations in the abundance of certain genera. The enriched functions and the altered gut microbiota in the two groups had their enriched functions. Conclusion: The use of antibiotics affects the gut microbiota of CCP, but the effect of disease on gut microbiota is still obvious, which may help diagnosis and further investigation into the pathogenic mechanisms of CP. Chronic pancreatitis (CP) is a persistent fibro-inflammatory process of the pancreas associated with genetic, environmental, and other pathogenic factors. This disease eventually led to the pancreas' irreversible injury and increased risk of pancreatic cancer and impaired mental health [1-3].

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Section: Discussionmentioning

confidence: 99%

Effect of Antibiotics on The Gut Microbiota in Children with Chronic Pancreatitis

Wang¹,

Yuan²,

Ma³

et al. 2021

JJGH

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“…Sebanyak 59,6% pasien menerima antibiotik empiris secara irasional. 9 Di Indonesia sendiri penggunaan antibiotik yang irasional masih banyak terjadi. Sebuah penelitian yang dilakukan di rumah sakit pendidikan di Indonesia, 84% pasien menerima terapi antibiotik dan 60% diantaranya menerima terapi antibiotik yang irasional atau tanpa indikasi yang jelas.…”

Section: Penggunaan Antibiotik Pada Anak Dengan Sakit Kritis DI Picuunclassified

Penggunaan Antibiotik Irasional pada Pasien Anak dengan Sakit Kritis di Unit Perawatan Intensif Anak

Suriadi,

Sofian,

Beyeng

2024

J Indon Med Assoc

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Pasien di Unit Perawatan Intensif Anak (PICU), selain menghadapi penyakit dasar, juga berisiko tinggi mengalami infeksi sekunder. Kondisi ini disebabkan oleh banyaknya prosedur medis, penggunaan alat-alat invasif, dan lamanya durasi perawatan. Memberikan antibiotik kepada hampir semua pasien PICU, meskipun tanpa tanda-tanda infeksi, telah menjadi praktik umum. Tujuan dari studi ini adalah mengetahui gambaran dan dampak dari penggunaan antibiotik irasional (baik sebagai terapi empiris, profilaksis maupun sebagai terapi definitif), serta mengetahui peran biomarker sebagai acuan pertimbangan pemberian antibiotik pada pasien anak di PICU. Penggunaan antibiotik yang irasional pada anak yang dirawat di PICU masih terjadi di berbagai belahan dunia, baik sebagai terapi empiris, profilaksis maupun sebagai terapi definitif. Hal ini dapat berdampak pada meningkatnya kejadian resistensi antibiotik, memperpanjang durasi perawatan, meningkatkan beban ekonomi masyarakat, dan paling parah dapat meningkatkan angka kematian akibat infeksi. Pemeriksaan PCT dan CRP telah terbukti memiliki kaitan dengan tingkat keparahan penyakit, kedua marker tersebut berperan membedakan etiologi (infeksi vs non-infeksi) pada pasien sehingga dapat memandu inisiasi, deeskalasi, atau penghentian antibiotik. Untuk mengurangi resistensi antibiotik, penting dilakukan edukasi berkala kepada tenaga medis tentang protokol pemberian antibiotik mencakup indikasi, jenis, dosis dan lama pemberian. Dapat pula disediakan form tertulis untuk menilai keperluan terapi dengan menggunakan alur Gyssens. Dibutuhkan kerja sama dari berbagai pihak agar strategi penanganan dapat berjalan secara komprehensif dan berkesinambungan.

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“…(10)(11)(12)(13)(14)(15)(16)(17)(18) These drug resistant strains have become global health crises and an emergency. Factors associated with antibiotic use are both community and hospitals based as studies have reported increased use of antibiotics by parents and caregivers as well as health care providers ( (19)(20)(21)(22)(23)(24)(25). It is therefore imperative to monitor and control antibiotic prescribing to ensure judicious use, prevent resistance and reduce cost of healthcare.…”

Section: Introductionmentioning

confidence: 99%

Point Prevalence Surveys of Antibiotic Prescribing in Children at a Tertiary Hospital in a resource constraint, low- income sub-Saharan African country.

Akintan

Oshun

Osuagwu

et al. 2022

Preprint

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Background Antibiotic resistance has been widely described in children by various pathogens to multiple antibiotics, these have become a global health crisis and an emergency. Factors associated with antibiotic use are both community and hospital based as studies have reported increased use of antibiotics by parents and caregivers as well as health care providers This study aimed to describe prevalence rates of antibiotic prescribing and evaluate antibiotic prescribing practices as well as targets for improving the quality of antimicrobial prescribing in children over time. Method Point prevalence survey of antimicrobial use was performed yearly for 4 years to monitor trends in antimicrobial prescribing., Data from all patients admitted before 8 am on the day of the PPS were included. A web-based application designed by the University of Antwerp was used for data-entry, validation and analysis (http://www.global-pps.com). Results A total of 260 children including 90 (34.6%) neonates and 170 (65.4%) older children were admitted during the four surveys. Overall, 179 (68.8%) patients received at least one antibiotic. In neonates, the prevalence of antibiotic use increased from 78.9–89.5% but reduced from 100–58.8% in older children. There was a reduction in the use of antibiotics for prophylaxis from 45.7–24.6%. The most frequently prescribed antibiotic groups were third generation cephalosporins and aminoglycosides. The most common indication for antibiotic prescribing was sepsis in neonates and central nervous system infection in older children. The documentation of reason in notes increased from 33–100% while stop review date also increased from 19.4–82.1%. Conclusion The prevalence of antibiotic use was high with cephalosporins being the most prescribed antibiotic.

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Analysis of antibiotic treatment of children in a Shanghai tertiary hospital based on point prevalence surveys

Cited by 10 publications

References 30 publications

Effect of Antibiotics on The Gut Microbiota in Children with Chronic Pancreatitis

Effect of Antibiotics on The Gut Microbiota in Children with Chronic Pancreatitis

Penggunaan Antibiotik Irasional pada Pasien Anak dengan Sakit Kritis di Unit Perawatan Intensif Anak

Point Prevalence Surveys of Antibiotic Prescribing in Children at a Tertiary Hospital in a resource constraint, low- income sub-Saharan African country.

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