Analysis of antinociceptive effects of flurbiprofen enantiomers in a rat model of arthritic pain

Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co‐Administration in an Arthritic Gout‐Type Pain in Rats

“…Conversely, rac ‐Flur showed antinociceptive effects dose dependent, this effect was mainly due to the activity of the enantiomer S (+)‐flurbiprofen, because when we compare the results of rac‐ Flur and R (‐)‐flurbiprofen, the latter did not show antinociceptive activity. These results are similar to previous reports in the literature, where it has been reported that the S (+)‐flurbiprofen is acting as an inhibitor of cyclooxigenase, while the R (‐)‐flurbiprofen have not antinociceptive effects at different doses [Malmberg and Yaksh, ; Carabaza et al, ; López‐Muñoz et al, ].…”

“…The antinociceptive effects of flurbiprofen are due to the S‐enantiomer [López‐Muñoz et al, ]. However, we are evaluating the racemic mixture, so to corroborate that the effects we are getting are due to the presence of the active enantiomer, we evaluate the effects of “ R ” enantiomer of flurbiprofen in this model, the results are shown in Figure , in which can be observed that R ‐flurbiprofen did not show antinociceptive effects in contrast with the effects obtained with the racemic mixture.…”

“…The use of NSAIDs for the treatment of painful conditions in which inflammatory processes are involved is very common [Simon, ; Ong et al, ], within this group is the compound flurbiprofen (2‐(2‐fluoro‐4‐biphenyl) propionic acid). Flurbiprofen is a NSAID used primarily as a racemic mixture (rac‐Flur), however it is known that the main anti‐inflammatory and analgesic effect is due to enantiomer S (+) Flurbiprofen [López‐Muñoz et al, ], which acts, between others mechanisms of action, as an cyclooxygenase inhibitor [Carabaza et al, ]. This compound is widely used to treat arthritic pain conditions such as rheumatoid arthritis and osteoarthritis [López‐Muñoz et al, ; Sugimoto et al, ].…”

“…Flurbiprofen is a NSAID used primarily as a racemic mixture (rac‐Flur), however it is known that the main anti‐inflammatory and analgesic effect is due to enantiomer S (+) Flurbiprofen [López‐Muñoz et al, ], which acts, between others mechanisms of action, as an cyclooxygenase inhibitor [Carabaza et al, ]. This compound is widely used to treat arthritic pain conditions such as rheumatoid arthritis and osteoarthritis [López‐Muñoz et al, ; Sugimoto et al, ].…”