Analysis of antiproliferative effect of Chamerion angustifolium water extract and its fractions on several breast cancer cell lines

Maruška, Audrius; Ugenskienė, Rasa; Raulinaitytė, Danguolė; Juozaitytė, Elona; Kaškonienė, Vilma; Drevinskas, Tomas; Stelmakienė, Ada; Akuņeca, Ieva; Makaravičius, Tomas; Tiso, Nicola; Bartkuvienė, Violeta; Kornyšova, Olga; Ragažinskienė, Ona; Ramanauskienė, Kristina; Briedis, Vitalis

doi:10.1016/j.advms.2016.08.002

Cited by 13 publications

(16 citation statements)

References 18 publications

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“…Extracts at concentration of 50-75 µg/ml reduced cell viability and induced DNA damages in hepatocellular carcinoma. The inhibition of growth and proliferation of some breast cancer cell lines exposed to E. angustifolium extracts was also reported [28]. In turn, antiproliferative activity of fireweed water extract and oenothein B in in vitro and in vivo models was described by Piwowarski et al [15].…”

Section: Antiproliferative and Cytotoxic Activitiesmentioning

confidence: 90%

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

et al. 2020

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SummaryFireweed (Epilobium angustifolium L.) is a well-known medicinal plant traditionally used in the treatment of urogenital diseases, stomach and liver disorders, skin problems, etc. E. angustifolium extracts show anti-androgenic, antiproliferative, cytotoxic, antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial activities. The unique combination of biological properties demonstrated by the results of some studies indicates that fireweed has a positive effect in benign prostatic hyperplasia (BPH) and potentially in the prostate cancer chemoprevention. However, the efficacy of E. angustifolium phytotherapy is still poorly tested in clinical trials, while numerous beneficial effects of extracts have been documented in the in vitro and in vivo tests. Fireweed is rich in polyphenolic compounds, particularly ellagitannins. Currently, polyphenols are considered to be modulators of beneficial gut microbiota. The literature data support the use of ellagitannins in the prostate cancer chemoprevention, but caution is advised due to the highly variable production of urolithins by the individual microbiota. A better understanding of the microbiota’s role and the mechanisms of its action are crucial for an optimal therapeutic effect. This paper aims to summarize and discuss experimental data concerning pharmacological properties of E. angustifolium and bioavailability of ellagitannins – important bioactive compounds of this plant.

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Section: Antiproliferative and Cytotoxic Activitiesmentioning

confidence: 90%

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

et al. 2020

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“…If (i) medium electrophoretic mobility cations have a lower normalized value than -0.83, the extract is non-cytoxic. If medium (6), G. macrorrhizum (7), M. officinalis (8), A. archangelica aerial part (9), A. archangelica root (10), T. vulgaris (11), H. officinalis (12), N. cataria (13), E. purpurea (14), S. officinalis (15) Multimensional scaling of plant extracts electrophoretic mobility cations have a higher normalized value than -0.83, the extract is cytotoxic with a probability of 75%. If (ii) the extract in the second level has the normalized value of low electrophoretic mobility cations lower than -0.84, the extracts are non-cytotoxic.…”

Section: Data Mining and Chemometricsmentioning

confidence: 99%

“…Gas chromatography is mainly used for separation of volatile compounds [10]. Liquid chromatography in the reversed phase mode is mainly used for separating substances according to their different pollarity [11]. Spectrophotometric assays are also used.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic attributes of antiviral plants rich in polyphenolic and volatile compounds

Drevinskas¹,

Mickienė²,

Maruška³

et al. 2018

chemija

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The application of natural products for treatment and prevention of various diseases is becoming more important. Not only antibacterial natural preparations are being developed, but also antiviral natural products are investigated. There are two main problems in such investigations: (i) special chemical analysis and data analysis methods have to be used, (ii) not only antiviral effect has to be taken into account, but also cytotoxic and other unwanted effects. In this work, a combination of separation methods (capillary electrophoresis and gas chromatography), spectrophotometric methods, data mining/data analysis methods (hierarchical clusterization, multidimensional scaling and classification and regression tree induction) for clarifying chemical attributes in cytotoxic plant extracts was applied. The selected plants belonged to families: (i) Lamiaceae, (ii) Asteraceae and (iii) Fabaceae. Most cytotoxic were Agastache foeniculum Pursh. Kuntze. and Salvia officinalis L. extracts. Least cytotoxic were Perilla frutescens L. and Satureja Montana L. extracts. The tendency of cytotoxic extracts having abundant concentrations of medium and low electrophoretic mobility cations was clarified.

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“…Therefore, the ability of a compound to interact with cells is very important for its biological activity. A large number of trials for investigating bioactive components have been applied to the research and development of herbal medicines using various types of cells in recent years (Huang & Yu, ; Maruška et al, ; Varasteh‐Kojourian et al, ). HepaRG cells are human cell lines derived from hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Multicomponent determination of traditional Chinese medicine preparation yin‐zhi‐huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells

Rao

Zhang

et al. 2017

Biomedical Chromatography

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Yin-zhi-huang (YZH) injection is an injectable multiherbal prescription derived from the ancient Chinese medicine formula of Yin-chen-hao-tang, which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, the systematic study of the components in this multiherbal prescription still lacks suitable analytical methods that are able to simultaneously detect a broad array of components at low concentrations. In this study, a new liquid chromatography-tandem mass spectrometry method using dynamic multiple reaction monitoring mode was developed to determine multiple peaks in traditional Chinese medicine preparation YZH injection. This simple, selective and sensitive method enabled the quantification of 22 components with standard materials with a lower limit of quantification of 1.46-12.5 ng/mL in cell lysates. This method was successfully applied to celluar uptake and binding investigation of components in YZH injection. The results indicated that this strategy might be a useful approach for rapidly screening of the potential bioactive candidates from YZH injection, and the discovered candidates could be used to investigate the pharmacodynamics in further studies.

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Analysis of antiproliferative effect of Chamerion angustifolium water extract and its fractions on several breast cancer cell lines

Cited by 13 publications

References 18 publications

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review

Cytotoxic attributes of antiviral plants rich in polyphenolic and volatile compounds

Multicomponent determination of traditional Chinese medicine preparation yin‐zhi‐huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells

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