Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data

Wilkins, John T.; Ning, Hongyan; Sniderman, Allan D.; Stone, Neil J.; Otvos, James D.; Jacobs, David R; Shah, Ravi; Murthy, Venkatesh L.; Rana, Jamal S.; Allen, Norrina B; Lloyd-Jones, Donald M

doi:10.1016/j.jlr.2022.100299

Cited by 3 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, a physiological decrease with age should not be excluded. Yearly ApoB changes, including increase or decrease, have been demonstrated in young adulthood through life, but no data are available in children [28]. This is an important point, requiring further tests to confirm and understand this trend.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Martino,

Niglio,

Martino

et al. 2024

JCDD

View full text Add to dashboard Cite

Rationale. The prevention of cardiovascular (CV) disease is mandatory from childhood onwards. Among biochemical markers related to the clinical cardiovascular outcome, LDL cholesterol (LDL-C), non-HDL-C and apolipoprotein B (ApoB) are recognized as main target parameters. Emphasis on ApoB concentrations is growing, as representative of any class of atherogenic lipoprotein. This consideration allows checking of subjects under 18 years of age when the CV risk occurs. The aim of this study is to evaluate ApoB levels in a sample of Italian hyperlipidemic children and adolescents, and their siblings, to test any relationship with their lipid profile. Methods. A retrospective study, including 1877 children and adolescents (aged 0–18 years), was performed. Clinical and biochemical data were selected from a database, including the lipid profile, ApoB analysis and anthropometric parameters of any proband. Participants had been checked as potentially hyperlipidemia affected, the suspicion raised by familial CV risk or because the dyslipidemia was already known. Data from the first visit at the University Hospitals in Rome and Turin were collected. Patients affected by secondary hyperlipidemia or obesity were excluded. Blood test analysis was performed in fasting conditions by automated commercial kits. Participants were classified according to gender, age (stratified in subgroups: 0–5, 6–10, 11–14, and 15–18 years old) and anthropometric parameters, referred to as weight in Kg and height in cm, and BMI calculated. Lipid profile results were stratified in relation to acceptable, borderline, or increased levels, as indicated by NCEP, and any potential relation with ApoB established. Statistics were performed by Epi-Info 7 programs to evaluate the variance analysis. Either parent could sign the informed consent. Results. Among the whole sample n.1010 and n.867 participants were females and males, respectively. TC values acceptable (≤170 mg/dL), borderline (171–200 mg/dL) and elevated (≥201 mg/dL) were found in 411 (22%), 585 (31%) and 881 (47%) participants, respectively. The LDL-C cut-off considered was 110 mg/dL (90° percentile). Mean ApoB progressively increased from 65 to 110 mg/dL according to TC levels and resulted in significant correlation when any age subgroup and gender was considered. The highest ApoB values, TC and LDL-C related, were found in the youngest subgroup, regardless of gender. Conclusion. ApoB results increase progressively and in parallel with TC and LDL-C and represent a further parameter to distinguish between normal and hyperlipidemic subjects. Serum levels are close to 70 mg/dL and to 100 mg/dL in the former and latter group, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

“…More recently, the association of ApoB/ApoA1 ratio with future CV risk was demonstrated [29] in 396 children and adolescents and the predictive value of ApoB established alongside the changes occurring at different ages [28].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B and Lipid Profile in Italian Children and Adolescents

Martino,

Niglio,

Martino

et al. 2024

JCDD

View full text Add to dashboard Cite

show abstract

“…Individual uncertainty, of course, will remain. 66 , 67 The greater the deviation from the norm, the more likely the deviance is to remain; nevertheless, regression to the mean will occur. Physiological and lifestyle changes will, undoubtedly, affect the levels of the apoB lipoproteins in individuals.…”

Section: Limitations Of All Predictive Modelsmentioning

confidence: 99%