Analysis of asbestos fibers and asbestos bodies in tissue samples from human lung. An international interlaboratory trial.

Gylseth, B; Churg, Andrew; Jm, Davis; Johnson, Neil; Morgan, A.; Mowé, G; Rogers, AJ; Roggli,

doi:10.5271/sjweh.2246

Cited by 75 publications

(22 citation statements)

References 5 publications

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“…Only a few studies have examined the relationship between fiber burden and time since last exposure, and there is a major problem in using these reports to estimate clearance half-times, since absolute fiber concentrations for any specimen are known to vary markedly from laboratory to laboratory (31). Nonetheless, these studies are consistent in that, where rates can be estimated, the clearance half-times for amphiboles are generally fairly long, ranging from years to decades (Table 3; Figure 2).…”

Section: Fiber Burden In Relation Tomentioning

confidence: 99%

Persistence of Natural Mineral Fibers in Human Lungs: An Overview

Churg¹,

Wright²

1994

Environmental Health Perspectives

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Virtually all available data on persistence of naturally occurring mineral fibers in human lungs have been derived from studies of asbestos fiber loads. These studies indicate that, although both amphibole and chrysotile asbestos fibers are found in the lungs of the general population and exposed workers, amphibole fibers are universally present in disproportionately large and chrysotile fibers in disproportionately small amounts compared to their known abundance in the original inhaled dusts. Why this should be remains unclear. Most reports have shown that fiber accumulation is proportional to measured exposure for amphiboles, but this is not generally true for chrysotile. Very little information is available on actual fiber clearance rates from human lungs. For amosite and crocidolite, estimated clearance half-times are measured in years to decades, whereas for chrysotile the available, rather indirect, data suggest that the vast majority of fibers are cleared within months, although some fibers may be sequestered and very slowly cleared. Overall these studies suggest that the differences between amphibole and chrysotile fiber burdens in man reflect much faster clearance of chrysotile fibers, rather than a failure of chrysotile deposition. A variety of other naturally occurring fibers are commonly found in human lungs, but there are no data on their rates of accumulation or disappearance. -Environ Health Perspect 1 02(Suppl 5): 229-233 (1994)

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Section: Fiber Burden In Relation Tomentioning

confidence: 99%

Persistence of Natural Mineral Fibers in Human Lungs: An Overview

Churg¹,

Wright²

1994

Environmental Health Perspectives

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“…Lung analysis may reveal occult exposures that are not apparent from the work history. Concentration limits to indicate occupational exposure have been proposed and established for each laboratory because of the analytical variability [Gylseth et al, , 1985Rodelsperger et al, 19901. In addition to the fiber concentration, the fiber types found in the lungs can give information about the exposure conditions.…”

Section: Introductionmentioning

confidence: 99%

Fibrous minerals in the lungs of mesothelioma patients: Comparison between data on SEM, TEM, and personal interview information

Tuomi

1992

American J Industrial Med

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To determine and compare the fiber types and size distributions in the lung tissue of mesothelioma patients in Finland, samples from 29 patients with known work history were analyzed with transmission electron microscopy (TEM) and X-ray microanalysis. Compared with the earlier results using scanning electron microscopy (SEM), the fiber concentrations were about three times as high and ranged from 0.1 million to 5,200 million fibers per gram of dry tissue. In 15 patients (52%), crocidolite/amosite were the dominating fiber types, representing more than 70% of all fibers. Anthophyllite asbestos was the most prevalent fiber type in eight patients (28%), and it was found in the samples of 13 patients (45%). One-half of the anthophyllite fibers were longer than 5 microns, whereas other fiber types were somewhat smaller.

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“…When the relationship between AB concentration and total fibre burden is interpreted, it must be emphasized that wide interlaboratory variation occurs in the determination of pulmonary fibre concentrations with electron microscopy [19].…”

Section: Discussionmentioning

confidence: 99%

Asbestos bodies in bronchoalveolar lavage in relation to asbestos bodies and asbestos fibres in lung parenchyma

Karjalainen

Piipari²,

Mäntylä³

et al. 1996

Eur Respir J

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In Finland, unlike other countries, anthophyllite asbestos has been widely used due to its domestic production in . In this particular context, the aim of the present study was to analyse the relationship between asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid and the concentration of ABs and the different amphibole asbestos fibres in lung tissue.Sixty five BAL lung tissue sample pairs from patients with pulmonary disease were analysed. The concentration of ABs in BAL fluid and lung tissue was determined with optical microscopy, and the concentration, type and dimensions of asbestos fibres in lung tissue with scanning electron microscopy.There was a significant correlation between the concentrations of ABs in BAL fluid and in lung tissue (r=0.72; p<0.001), between the concentrations of ABs and amphibole asbestos fibres in lung tissue (r=0.73; p<0.001), and between the concentration of ABs in BAL fluid and the concentration of amphibole asbestos fibres in lung tissue (r=0.64; p<0.001). In patients who had been exposed mainly to commercial anthophyllite, significantly higher concentrations of ABs were observed per total pulmonary amphibole fibre burden, as compared to patients whose main exposure was to crocidolite/amosite. The anthophyllite fibres in lung tissue were longer than the crocidolite/amosite fibres.The relationship between asbestos body counts in lung tissue and in bronchoalveolar lavage fluid was similar to previous international observations. When using the asbestos body count to predict the underlying total pulmonary amphibole asbestos burden in Finnish patients, however, it should be borne in mind that the relationship between the two parameters seems to be different with anthophyllite as compared to crocidolite/amosite fibres.

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Analysis of asbestos fibers and asbestos bodies in tissue samples from human lung. An international interlaboratory trial.

Cited by 75 publications

References 5 publications

Persistence of Natural Mineral Fibers in Human Lungs: An Overview

Persistence of Natural Mineral Fibers in Human Lungs: An Overview

Fibrous minerals in the lungs of mesothelioma patients: Comparison between data on SEM, TEM, and personal interview information

Asbestos bodies in bronchoalveolar lavage in relation to asbestos bodies and asbestos fibres in lung parenchyma

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