Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly

Степанов, В. Г.; Вагайцева, К. В.; Бочарова, А. В.; Marusin, Andrey; Markova, Valentina V.; Minaycheva, L. I.; Makeeva, O. A.

doi:10.1155/2018/2686045

Cited by 9 publications

(8 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, we do not know much about the specific functions of LUZP2 and the articles about LUZP2 are very few. LUZP2 has been reported to be deleted in patients with Wilms' tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome, which is a scarce congenital anomaly syndrome consisting of Wilms' tumor, genital anomalies, aniridia, and mental retardation [ 7 , 8 ]. It is reported that polymorphic variants in this gene are associated with the late-onset Alzheimer's disease and schizophrenia [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma

Deng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Background. LUZP2 is a protein limitedly expressed in the brain and spinal cord, while there are few studies on it in brain tumors. Low-grade glioma (LGG) is one of the most common brain tumors. However, the biological behavior of LGG is not very clear at present. This study was aimed at exploring the role of LUZP2 in LGG. Methods. By data mining in The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), the expression, clinical characteristics, and potential regulatory mechanism of LUZP2 in LGG were assessed. The regulatory miRNAs of LUZP2 were predicted using miRDB, TargetScan, and miRTarBase. Meanwhile, the potential biological function of coexpressed genes was investigated by GO and KEGG analyses. Results. LUZP2 expression was downregulated with the increase of tumor grade (p<0.05). Low LUZP2 expression independently predicted poor OS in LGG in TCGA cohort and the CGGA part B and part C cohorts (all p<0.001). Additionally, LUZP2 was targeted by miR-142-5p according to 2 prediction databases and 1 validated database, which was negatively related to LUZP2 mRNA expression (p<0.001). Kaplan-Meier analyses demonstrated that low miR-142-5p expression was significantly associated with poor OS (p<0.001). Furthermore, coexpression genes of LUZP2 were significantly involved in nervous system development and metabolic pathways.Conclusions. LUZP2 may be crucial for nervous system extracellular matrix development and serve as an important clinical biomarker for LGG patients. miR-142-5p upregulation could be the upstream regulator that contributed to LUZP2 downregulation.

show abstract

Section: Introductionmentioning

confidence: 99%

Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma

Deng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…LUZP2 (leucine zipper protein 2 gene), located on Chr 11p13–11p14 and encoding a leucine zipper protein, has been shown to be deleted in Wilms' tumor patients. Wilms' tumor, genital abnormalities, aniridia, and mental retardation is a rare congenital abnormality syndrome characterized by Wilms' tumor, genital deformities, aniridia, and mental retardation [ 24 , 25 ]. Furthermore, Zhao et colleagues found that LUZP2 mRNA expression is elevated in hormone-naive prostate cancer (PC) relative to normal prostate tissues, but downregulated throughout the progression from hormone-naive PC to castration-resistant PC (CRPC) [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Construction and evaluation of a prognostic risk model of tumor metastasis-related genes in patients with non-small cell lung cancer

Ding

Chen³

et al. 2022

BMC Med Genomics

View full text Add to dashboard Cite

Background Lung cancer is a high-incidence cancer, and it is also the most common cause of cancer death worldwide. 80–85% of lung cancer cases can be classified as non-small cell lung cancer (NSCLC). Methods NSCLC transcriptome data and clinical information were downloaded from the TCGA database and GEO database. Firstly, we analyzed and identified the differentially expressed genes (DEGs) between non-metastasis group and metastasis group of NSCLC in the TCGA database, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) were consulted to explore the functions of the DEGs. Thereafter, univariate Cox regression and LASSO Cox regression algorithms were applied to identify prognostic metastasis-related signature, followed by the construction of the risk score model and nomogram for predicting the survival of NSCLC patients. GSEA analyzed that differentially expressed gene-related signaling pathways in the high-risk group and the low-risk group. The survival of NSCLC patients was analyzed by the Kaplan–Meier method. ROC curve was plotted to evaluate the accuracy of the model. Finally, the GEO database was further applied to verify the metastasis‑related prognostic signature. Results In total, 2058 DEGs were identified. GO functions and KEGG pathways analysis results showed that the DEGs mainly concentrated in epidermis development, skin development, and the pathway of Neuro active ligand -receptor interaction in cancer. A six-gene metastasis-related risk signature including C1QL2, FLNC, LUZP2, PRSS3, SPIC, and GRAMD1B was constructed to predict the overall survival of NSCLC patients. The reliability of the gene signature was verified in GSE13213. The NSCLC patients were grouped into low-risk and high-risk groups based on the median value of risk scores. And low-risk patients had lower risk scores and longer survival time. Univariate and multivariate Cox regression verified that this signature was an independent risk factor for NSCLC. Conclusion Our study identified 6 metastasis biomarkers in the NSCLC. The biomarkers may contribute to individual risk estimation, survival prognosis.

show abstract

“…As a result, we can project our expectations onto LUZP2 [ 34 ]. Downregulation of LUZP2 is linked to cellular senescence [5, which has been linked to a number of age-related diseases [ 13 , 14 , 15 , 16 ]. Only the brain and the adrenal glands have higher levels of LUZP2 expression [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…LUZP2 is found on Chr11p13–11p14 and encodes a leucine zipper protein, the deletion of which has been linked to low grade glioma, Alzheimer's disease, and schizophrenia [ 11 , 12 , 13 , 14 , 15 ]. Zhao et al.…”

Section: Introductionmentioning

confidence: 99%