Analysis of azanphthalenes and their enzyme oxidation products by high-performance liquid chromatography, infrared spectroscopy and mass spectrometry

Stubley, C.; Stell, J. G. P.; Mathieson, D. W.

doi:10.1016/s0021-9673(01)96327-7

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…The mass spectrum obtained from metabolite I1 contained an apparent molecular ion [M'] at m/z 146 and major fragment ions at m/z 118, 91, 64 and 63. It was identical to that of 2( 1H)-quinoxalinone (Stubley et al 1979).…”

mentioning

confidence: 53%

Biotransformation of quinoxaline by Streptomyces badius

Sutherland

Evans

Freeman

et al. 1996

Lett Appl Microbiol

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confidence: 53%

Biotransformation of quinoxaline by Streptomyces badius

Sutherland

Evans

Freeman

et al. 1996

Lett Appl Microbiol

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“…The residue was subjected to examination by mass spectrometry and i.r. spectroscopy as previously described (Stubley et al 1979b).…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

Reaction of 1-amino- and 1-chlorophthalazine with mammalian molybdenum hydroxylasesin vitro

1987

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1-Amino- and 1-chlorophthalazine were tested for possible substrate activity with partially purified rabbit-liver aldehyde oxidase and bovine-milk xanthine oxidase. 1-Chlorophthalazine was a more efficient substrate than the parent compound, phthalazine, with either aldehyde oxidase or xanthine oxidase. The oxidation product of 1-chlorophthalazine was identified as 4-chloro-1-(2H)-phthalazinone on the basis of chromatographic, infra-red and mass-spectral data. 1-Aminophthalazine was oxidized by aldehyde oxidase to 4-amino-1-(2H)-phthalazinone but was a competitive inhibitor of xanthine oxidase. Kinetic studies at different pH values indicated that, in each case, it is the unprotonated form of 1-aminophthalazine that reacts with the molybdenum hydroxylases.

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“…1957, 29, 1489-1491. (12) Novotny, M.; Lee, M. L.; Bartle, K. D. Chromatographia 1974, 7 (7), 333-338.…”

Section: Literature Citedmentioning

confidence: 99%

“…Previous chromatographic determinations of amines and azaarenes were performed in various ways. Work with HPLC resulted in separations via both the reversed-phase and normal-phase modes (7)(8)(9). Various mobile phase systems and columns were employed in these studies to separate azaarene compounds containing one to several rings.…”

Section: Literature Citedmentioning

confidence: 99%