The Kenics static mixer is expected to enhance the extraction performance to reduce the burden of the extraction column in the phenolic wastewater treatment process. Currently, it has been deployed as a pre-extractor in a newly built project of 35 m 3 /h wastewater treatment in Datang coal gasification corporation. The fluctuating flow rate brings instability of the extraction performance. However, few studies have paid attention to the mass transfer performance in demo-or commercial-sized static mixers. Thus, this work adopted a three-dimensional model coupled with the CFD-PBE model, the interphase mass transfer model, and the interface mass transfer−droplet size effect function in the simulation of various sizes of Kenics static mixers to describe the droplet size distribution and mass transfer performance. Besides, to increase the accuracy of extraction performance prediction, the eddy cell model and droplet size effect model were introduced to correct the mass transfer performance and droplet size distribution prediction with the change of equipment size and operation flowing velocity. In the simulations, it was found that the greater static mixer size can achieve better mass transfer performance with fewer mixing elements but translated into a lower time efficiency. It was also found that each size Kenics static mixer featured an optimal total flowing velocity, achieving the maximum extraction efficiency in catechol extraction. The extraction efficiencies peaked at total flowing velocities of 0.8, 1.1, 1.2, and 1.2 m/s, with diameters of 30, 100, 200, and 300 mm, respectively. The characteristics of the change in turbulence dissipation rate, turbulent viscosity, and interfacial tension are key factors in the explanation of these phenomena. In each size static mixer, under the respective optimal flowing velocity, the mass fraction of catechol in the aqueous phase meets the criterion of biochemical treatment process influent after continuous two-stage extraction.