2016
DOI: 10.1016/j.jpba.2015.12.032
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Analysis of bioactive components and pharmacokinetic study of herb–herb interactions in the traditional Chinese patent medicine Tongmai Yangxin Pill

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Cited by 29 publications
(21 citation statements)
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“…It might result from hepatoenteral circulation. One peak plasma concentration-time profiles of liquiritigenin, isoliquiritigenin, and glycyrrhizic acid were reported in rat plasma following oral administration of Radix glycyrrhizae or the combination of Radix glycyrrhizae and Ramulus cinnamomi [ 8 ]. The differences may come from the effects of other herbs in TMYX which require further experiment.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…It might result from hepatoenteral circulation. One peak plasma concentration-time profiles of liquiritigenin, isoliquiritigenin, and glycyrrhizic acid were reported in rat plasma following oral administration of Radix glycyrrhizae or the combination of Radix glycyrrhizae and Ramulus cinnamomi [ 8 ]. The differences may come from the effects of other herbs in TMYX which require further experiment.…”
Section: Resultsmentioning
confidence: 99%
“…Chen reported 80 compounds were identified or surmised using HPLC-MS, including 23 flavones and their glucuronides, 6 phenethyl alcohol glycosides, 20 triterpene saponins, 15 lignans, and 18 other compounds [ 13 ]. Fan characterized 40 absorbed bioactive components after oral administration of TMYX in rat serum by UPLC/Q-TOF-MS [ 14 ]. The 40 components including 2 from Radix rehmanniae , 10 from Radix codonopsis , 2 from Radix ophiopogonis , 2 from Ramulus cinnamomi , 19 from Radix glycyrrhizae , 2 from Radix polygoni multiflori preparata , 5 from Caulis spatholobi , 1 from Fructus jujubae, and 1 from Fructus schisandrae , some of which are overlapped.…”
Section: Introductionmentioning
confidence: 99%
“…It has been reported that the oral bioavailability of individual epimedin C was higher than that of Herba Epimedii extracts [22]. Our results, on the contrary, turned out that, after intramuscular administration of the purified extract to rats, the absorption and bioavailability of epimedin C enhanced significantly in comparison with those of individual epimedin C administered intramuscularly, which suggests other components in CKI could improve the bioavailability of epimedin C. Because of the synergistic effects of other herbs/components, Chinese herbal formula is usually more potent than individual herb/component, which has been confirmed by more and more researches on Chinese medicine formula such as Huangqin decoction [2427]. The purified herbal preparation might be more effective than individual epimedin C via intramuscular administration in clinical application.…”
Section: Resultsmentioning
confidence: 98%
“…TMYX, an effective patent medicine that is commonly used to treat CHD, arrhythmias, and HF, has bright clinical application prospects. With regard to the different pathophysiological factors of cardiac remodeling, previous studies of TMYX have indicated that TMYX can inhibit cardiac hypertrophy; decrease the apoptosis rate of myocardial cells; decrease anti-inflammatory, antioxidant, antiarrhythmic, and myocardial protection; promote angiogenesis; and ameliorate cardiac energy metabolism in a rat model of MI and ischemic reperfusion injury [12][13][14]. Currently, cardiac ultrasound (CUS) [5,15,16] and CMRI [5,17] are the major tools for the evaluation of ventricular remodeling and myocardial fibrosis at the international level.…”
Section: Discussionmentioning
confidence: 99%